G
Gordon L. Amidon
Researcher at University of Michigan
Publications - 469
Citations - 38521
Gordon L. Amidon is an academic researcher from University of Michigan. The author has contributed to research in topics: Intestinal absorption & Prodrug. The author has an hindex of 86, co-authored 466 publications receiving 35880 citations. Previous affiliations of Gordon L. Amidon include ETH Zurich & Merck & Co..
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A peptide prodrug approach for improving bisphosphonate oral absorption.
Aviva Ezra,Amnon Hoffman,Eli Breuer,Ivan S. Alferiev,Jukka Mönkkönen,N El Hanany-Rozen,G. Weiss,David Stepensky,Irith Gati,Hagit Cohen,Soili Törmälehto,Gordon L. Amidon,Gershon Golomb +12 more
TL;DR: The results indicate that the oral absorption of bisphosphonates can be improved by peptidyl prodrugs via the hPEPT1; however, other transporters may also be involved.
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Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.
TL;DR: It was revealed that the combined effect of P-gp and MRP2, but not BCRP, dominates colchicine transepithelial transport, leading to complete coverage of the entire small intestine, and makes the efflux transport dominate the intestinal permeability process.
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High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations
Arik Dahan,Jonathan M. Miller,John M. Hilfinger,Shinji Yamashita,Lawrence X. Yu,H Lennernäs,Gordon L. Amidon +6 more
TL;DR: It is shown that, in fact, there is no discrepancy between P(eff) and F(abs) in sotalol's absorption; the data emphasize that, if a compound has high fraction of dose absorbed, it will have high-permeability, not necessarily in the jejunum, but at some point along the relevant intestinal regions.
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Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity.
TL;DR: The present study demonstrated that the increase in viscosity of the dissolution medium, following ingestion of a solid meal, may drastically reduce disintegration and dissolution and show the necessity of considering media viscosities when designing in vitro models of drug release for BCS type III drug formulations.
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G.L. Amidon, H. Lennernas, V.P. Shah, and J.R. Crison. A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability, Pharm Res 12, 413–420, 1995—Backstory of BCS
Vinod P. Shah,Gordon L. Amidon +1 more
TL;DR: The Biopharmaceutics Classification System (BCS) has become widely accepted today in the academic, industrial, and regulatory world and has come to be utilized widely by the pharmaceutical industry in drug discovery and development as well.