G
Gordon L. Amidon
Researcher at University of Michigan
Publications - 469
Citations - 38521
Gordon L. Amidon is an academic researcher from University of Michigan. The author has contributed to research in topics: Intestinal absorption & Prodrug. The author has an hindex of 86, co-authored 466 publications receiving 35880 citations. Previous affiliations of Gordon L. Amidon include ETH Zurich & Merck & Co..
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A pH- and ionic strength-responsive polypeptide hydrogel: synthesis, characterization, and preliminary protein release studies.
TL;DR: The crosslinking of synthetic polypeptides with PEG appears to be a highly versatile approach to the preparation of pH-responsive biodegradable hydrogels.
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Passive and carrier-mediated intestinal absorption components of two angiotensin converting enzyme (ACE) inhibitor prodrugs in rats: enalapril and fosinopril.
TL;DR: The intestinal absorption mechanism of two ACE inhibitor prodrugs, enalapril and fosinopril, was investigated in rats using a single-pass perfusion method, indicating a nonpassive absorption mechanism via the small peptide carrier-mediated transport system.
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Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine: Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport
Xueqin Song,Philip L. Lorenzi,Christopher P. Landowski,Balvinder S. Vig,John M. Hilfinger,Gordon L. Amidon +5 more
TL;DR: The combined results suggest that the disposition of gemcitabine following oral administration would be controlled by the rate of bioconversion following transport across the intestinal epithelial membrane and that it may be possible to modulate these characteristics by the choice of the amino acid promoiety.
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Summary workshop report: Biopharmaceutics classification system—implementation challenges and extension opportunities
James E. Polli,Lawrence X. Yu,Jack Cook,Gordon L. Amidon,Ronald T. Borchardt,Beth A. Burnside,Philip S. Burton,Mei-Ling Chen,Dale P. Conner,Patrick J. Faustino,Amale A. Hawi,Ajaz S. Hussain,Hemant N. Joshi,Gloria Kwei,Vincent H.L. Lee,Lawrence J. Lesko,Robert A. Lipper,Alice E. Loper,Shriniwas G. Nerurkar,Joseph W. Polli,Dilip R. Sanvordeker,Rajneesh Taneja,Ramana S. Uppoor,Chandra S. Vattikonda,Ian R. Wilding,Guohua Zhang +25 more
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Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter
TL;DR: Caco-2/hPEPTl system is an efficient in vitro model for the uptake study of peptidyl derivatives and significantly improved the cellular uptake of the parent drugs via peptide transport mechanism and were rapidly converted to the active parent drugs by the intracellular hydrolysis.