Gordon L. Amidon

TL;DR: Comparison of gene expression profiles of Caco-2 cells generated with different arrays to assess the validity of conclusions derived from the 2 independent studies found similar results were obtained for most genes, despite differences in experimental conditions and array technology.

TL;DR: The observed patterns of emptying are consistent with the hypothesis that gastric emptying of nondigestible solids is governed in part by hydrodynamics and correlate well with the gastric-emptying coefficient (GEC), a dimensionless grouping of variables.

TL;DR: The creep compliance of latex films decreased with physical aging time, and the formation of films from aqueous latex dispersions is suggested to proceed gradually from the top to the bottom of the latex dispersion in this study.

TL;DR: The uptake kinetics of cephradine were studied in rat and rabbit intestinal brush border membrane vesicles preparations using both the Ca2+ and the Mg2+ methods of preparation, supporting the suggestion that they share the same peptide carrier pathway for oral absorption and that the vesicle may be a useful tool in developing orally effective peptide-type drugs.

TL;DR: In this article, a drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) for containing a drug (18) therein, and a plug (28) is disposed in a passageway (26) of the capsule half(12) for plugging the opening (24) thereof.