Gordon L. Amidon

TL;DR: The present work shows that the dependence of h(app) on particle size follows different functions in accordance with the paddle speed, and changes not only with particle size, but also with the hydrodynamics under standard USP configurations, which has been overlooked in the past.

TL;DR: The intestinal brush-border membrane system has the advantage of no cytosolic enzymes and that the uptake into the cytosol can be measured directly for both prodrug and drug concentration.

TL;DR: A series of amino acid monoester prodrugs of floxuridine was synthesized and evaluated for the improvement of oral bioavailability and the feasibility of target drug delivery via oligopeptide transporters and showed great potential for increased drug absorption and improved tumor selectivity and drug efficacy.

TL;DR: The rates of water sorption as a function of relative humidity for water-soluble substances exhibiting deliquescence have been measured in an atmosphere of pure water vapor and compared with a theoretical model, which relates the rate of water uptake to the transport of heat produced during the process away from the surface.

TL;DR: A BCS classification of CHMs according to biopharmaceutical properties of their AMCs is demonstrated to be feasible in the current study and can be used to provide a minimum set of quality standards.