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Gordon L. Amidon

Researcher at University of Michigan

Publications -  469
Citations -  38521

Gordon L. Amidon is an academic researcher from University of Michigan. The author has contributed to research in topics: Intestinal absorption & Prodrug. The author has an hindex of 86, co-authored 466 publications receiving 35880 citations. Previous affiliations of Gordon L. Amidon include ETH Zurich & Merck & Co..

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Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles.

Jayanth Panyam, +7 more
- 19 Sep 2003 - 
TL;DR: The polymer degradation rates in vitro were not substantially different for different size particles despite a 10- and 100-fold greater surface area to volume ratio for 0.1 microm size nanoparticles as compared to 1 and 10microm size microparticles, respectively.
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A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan.

Toshihide Takagi, +5 more
- 03 Oct 2006 - 
TL;DR: More than 55% of the drug products were classified as high-solubility (Class 1 and Class 3) drugs in the four lists, suggesting that in vivo bioequivalence (BE) may be assured with a less expensive and more easily implemented in vitro dissolution test.
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Targeted prodrug design to optimize drug delivery

Hyo Kyung Han, +1 more
- 01 Mar 2000 - 
TL;DR: This review highlights evolving strategies in targeted prodrug design, including antibody-directed enzyme prodrug therapy, genedirected enzyme pro drug therapy, and peptide transporter-associated prodrug Therapy.
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A compartmental absorption and transit model for estimating oral drug absorption.

Lawrence X. Yu, +1 more
- 20 Sep 1999 - 
TL;DR: A good correlation was found between the fraction of dose absorbed and the effective permeability for ten drugs covering a wide range of absorption characteristics, and the model was able to explain the oral plasma concentration profiles of atenolol.
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Caco-2 versus Caco-2/HT29-MTX Co-cultured Cell Lines: Permeabilities Via Diffusion, Inside- and Outside-Directed Carrier-Mediated Transport

Constanze Hilgendorf, +5 more
- 01 Jan 2000 - 
TL;DR: Co-cultures of HT29-MTX and Caco-2 cells offer the opportunity of modifying the permeability barrier of the cell monolayers both with respect to paracellular resistance and secretory transport via P-gp.