G
Gordon L. Amidon
Researcher at University of Michigan
Publications - 469
Citations - 38521
Gordon L. Amidon is an academic researcher from University of Michigan. The author has contributed to research in topics: Intestinal absorption & Prodrug. The author has an hindex of 86, co-authored 466 publications receiving 35880 citations. Previous affiliations of Gordon L. Amidon include ETH Zurich & Merck & Co..
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Journal ArticleDOI
Scaleup of immediate release oral solid dosage forms
Jerome P. Skelly,G. A. Van Buskirk,D. R. Savello,Gordon L. Amidon,H. M. Arbit,S. Dighe,M. Fawzi,Mario A. Gonzalez,A. W. Malick,H. Malinowski +9 more
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Comparison of several molecular topological indexes with molecular surface area in aqueous solubility estimation
Gordon L. Amidon,Shabbir Anik +1 more
TL;DR: The molecular topological indexes proposed by Wiener, Hosoya, and Randic were corelated with computed molecular surface areas and aqueous solubilities and it is indicated that all three indexes correlate with molecular surface area and, although computed in different manners, reflect molecular topology.
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The estimation of solubility in binary solvents: application of the reduced 3-suffix solubility equation to ethanol-water mixtures.
N.A. Williams,Gordon L. Amidon +1 more
TL;DR: The reduced 3-suffix solubility equation (R3SSE) is applied and predicts the mixed solvent solubilities of the compounds tested, as accurately as that obtained from several volume fractions.
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Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: The hidden role of bicarbonate buffer.
Daniela Amaral Silva,Jozef Al-Gousous,Neal M. Davies,Nadia Araci Bou Chacra,Gregory K. Webster,Elke Lipka,Gordon L. Amidon,Raimar Löbenberg +7 more
TL;DR: Approaches such as using simpler buffer systems instead of bicarbonate have been proposed as surrogate buffers to produce an equivalent buffer effect on drug dissolution on a case-by-case basis and they are discussed in this review.
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The "site of action"
TL;DR: The NRC FSME procedures are available through the NRC website and can be found in the FSME Procedure Contact section as discussed by the authors. But any changes to the procedure will be the responsibility of FSME procedure contact.