G
Gordon L. Amidon
Researcher at University of Michigan
Publications - 469
Citations - 38521
Gordon L. Amidon is an academic researcher from University of Michigan. The author has contributed to research in topics: Intestinal absorption & Prodrug. The author has an hindex of 86, co-authored 466 publications receiving 35880 citations. Previous affiliations of Gordon L. Amidon include ETH Zurich & Merck & Co..
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Patent
Soybean protein or hydrolyzates in pharmaceutical compositions to protect bioactive peptides from enzymatic inactivation
TL;DR: Proteins or peptidic substances, which may be prepared from naturally occurring proteins, enhance the bioavailability of proteolytically-labile therapeutic agents which would suffer enzymatic inactivation upon administration.
Journal ArticleDOI
Measurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.
Khaled Heissam,Nichola Abrehart,Caroline L. Hoad,Jeff Wright,Alex Menys,Kathryn Murray,Paul Glover,Geoffrey S. Hebbard,Penny A. Gowland,Jason Baker,William L. Hasler,Robin C. Spiller,Maura Corsetti,James G. Brasseur,Bart Hens,Kerby Shedden,Joseph Dickens,Deanna M. Mudie,Deanna M. Mudie,Greg E. Amidon,Gordon L. Amidon,Luca Marciani +21 more
TL;DR: Non-invasive dynamic magnetic resonance Imaging of gastric antral motility coupled with recently developed, semi-automated magnetic resonance imaging data processing techniques correlated well with simultaneous, ‘gold standard’ water perfused manometry.
Book ChapterDOI
Predicting Oral Drug Absorption in Humans: A Macroscopic Mass Balance Approach for Passive and Carrier-Mediated Compounds
TL;DR: There are several models for estimating drug absorption in humans, but prediction of absorption is semi-quantitative because of the high uncertainty in the extent and/or rate of oral drug absorption.
Book ChapterDOI
Overview of membrane transport.
Doo-Man Oh,Gordon L. Amidon +1 more
TL;DR: Identification, a better understanding of their transport characteristics, and the regulation of the membrane transporters will allow the development of better drug delivery strategies.