G
Graham H. Mitchell
Researcher at University of Essex
Publications - 84
Citations - 5483
Graham H. Mitchell is an academic researcher from University of Essex. The author has contributed to research in topics: Plasmodium knowlesi & Malaria. The author has an hindex of 40, co-authored 84 publications receiving 5259 citations. Previous affiliations of Graham H. Mitchell include King's College London & National Institutes of Health.
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Journal ArticleDOI
A Brief Illustrated Guide to the Ultrastructure of Plasmodium falciparum Asexual Blood Stages
TL;DR: An illustrated overview of the three-dimensional (3-D) organization of the merozoite, ring, trophozoite and schizont stages of the parasite, based on available data that include 3-D reconstruc-tion from serial electron microscope sections is given.
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Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Sharon Yeoh,Rebecca A. O'Donnell,Konstantinos Koussis,Anton R. Dluzewski,Keith H. Ansell,Simon A. Osborne,Fiona Hackett,Chrislaine Withers-Martinez,Graham H. Mitchell,L. H. Bannister,Justin S. Bryans,Catherine A. Kettleborough,Michael J. Blackman +12 more
TL;DR: The presence in the malarial parasitophorous vacuole of a regulated, PfSUB1-mediated proteolytic processing event required for release of viable parasites from the host erythrocyte is revealed.
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Apical Membrane Antigen 1, a Major Malaria Vaccine Candidate, Mediates the Close Attachment of Invasive Merozoites to Host Red Blood Cells
TL;DR: Apical membrane antigen 1 of Plasmodium merozoites may be directly responsible for reorientation or that the molecule may initiate the junctional contact, which is then presumably dependent on Duffy binding proteins for its completion.
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Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes
Robert W. Moon,Joanna Hall,Farania Rangkuti,YungShwen Ho,Neil Almond,Graham H. Mitchell,Arnab Pain,Anthony A. Holder,Michael J. Blackman +8 more
TL;DR: Human-adapted P. knowlesi clones maintain their capacity to replicate in monkey erythrocytes and can be genetically modified with unprecedented efficiency, providing an important and unique model for studying conserved aspects of malarial biology as well as species-specific features of an emerging pathogen.
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Molecular identification of a malaria merozoite surface sheddase.
Philippa K Harris,Sharon Yeoh,Anton R. Dluzewski,Rebecca A. O'Donnell,Chrislaine Withers-Martinez,Fiona Hackett,L. H. Bannister,Graham H. Mitchell,Michael J. Blackman +8 more
TL;DR: Proteolytic shedding of surface proteins during invasion by apicomplexan parasites is a widespread phenomenon, thought to represent a mechanism by which the parasites disengage adhesin-receptor complexes in order to gain entry into their host cell.