O
Orval A. Mamer
Researcher at McGill University
Publications - 154
Citations - 5664
Orval A. Mamer is an academic researcher from McGill University. The author has contributed to research in topics: Mass spectrometry & Taxus canadensis. The author has an hindex of 37, co-authored 154 publications receiving 5250 citations. Previous affiliations of Orval A. Mamer include Montreal Children's Hospital.
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Journal ArticleDOI
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
Brandon Faubert,Gino Boily,Said Izreig,Takla Griss,Bozena Samborska,Zhifeng Dong,Fanny Dupuy,Christopher Chambers,Benjamin J. Fuerth,Benoit Viollet,Benoit Viollet,Benoit Viollet,Orval A. Mamer,Daina Avizonis,Ralph J. DeBerardinis,Peter M. Siegel,Russell G. Jones +16 more
TL;DR: It is shown that AMPK negatively regulates aerobic glycolysis (the Warburg effect) in cancer cells and suppresses tumor growth in vivo, and that its loss fosters tumor progression in part by regulating cellular metabolic pathways that support cell growth and proliferation.
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The syndrome of systemic carnitine deficiency. Clinical, morphologic, biochemical, and pathophysiologic features.
George Karpati,Stirling Carpenter,Andrew G. Engel,Gordon V. Watters,Jeffrey C. Allen,Stanley Rothman,Gerald A. Klassen,Orval A. Mamer +7 more
TL;DR: Ketogenesis was impaired on a high fat diet, but omega oxidation of fatty acids was enhanced, and oral replacement therapy restored plasma carnitine levels to normal, but not liver or muscle carnite levels, and was accompanied by clinical improvement.
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The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
Przemyslaw Sapieha,Mirna Sirinyan,Mirna Sirinyan,David Hamel,Karine Zaniolo,Jean-Sébastien Joyal,Jean-Sébastien Joyal,Jang Hyeon Cho,Jean Claude Honoré,Elsa Kermorvant-Duchemin,Daya R. Varma,Sophie Tremblay,Martin Leduc,Lenka Rihakova,Pierre Hardy,William Klein,Xiuqian Mu,Orval A. Mamer,Pierre Lachapelle,Adriana Di Polo,Christian Beauséjour,Gregor Andelfinger,Grant A. Mitchell,Florian Sennlaub,Florian Sennlaub,Florian Sennlaub,Sylvain Chemtob +26 more
TL;DR: It is shown that succinate accumulates in the hypoxic retina of rodents and, via its cognate receptor G protein–coupled receptor-91 (GPR91), is a potent mediator of vessel growth in the settings of both normal retinal development and proliferative ischemic retinopathy.
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Coherent heterodyne time-domain spectrometry covering the entire “terahertz gap”
Nicholas Karpowicz,Jianming Dai,Xiaofei Lu,Yunqing Chen,Masashi Yamaguchi,Hongwei Zhao,Xi-Cheng Zhang,Lei Zhang,Cunlin Zhang,Matthew Price-Gallagher,Clark Fletcher,Orval A. Mamer,Alain Lesimple,Keith A. Johnson +13 more
TL;DR: In this article, the authors used gases ionized by femtosecond pulses to generate and sense broadband terahertz pulses using a coherent heterodyne technique, using a recycled optical probe beam and coherent detection, offers a high field strength and time-resolved measurement.
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Liquid chromatography/mass spectrometry analysis of mixtures of rhamnolipids produced by Pseudomonas aeruginosa strain 57RP grown on mannitol or naphthalene.
TL;DR: Liquid chromatography/mass spectrometry using electrospray ionisation was used to analyse rhamnolipids produced by a Pseudomonas aeruginosa strain with mannitol or naphthalene as carbon source, finding the most abundant rhamNolipid produced from naphtha contained two rham noses and one 3-hydroxydecanoic acid group.