G
Gualberto Ruaño
Researcher at Hartford Hospital
Publications - 97
Citations - 4166
Gualberto Ruaño is an academic researcher from Hartford Hospital. The author has contributed to research in topics: Population & VKORC1. The author has an hindex of 26, co-authored 92 publications receiving 3823 citations. Previous affiliations of Gualberto Ruaño include University of Georgia & University of Connecticut.
Papers
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Journal ArticleDOI
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.
Connie M. Drysdale,Dennis W. McGraw,Catharine B. Stack,J. Claiborne Stephens,Richard S. Judson,Krishnan Nandabalan,Kevin M. Arnold,Gualberto Ruaño,Stephen B. Liggett +8 more
TL;DR: The results indicate that the unique interactions of multiple SNPs within a haplotype ultimately can affect biologic and therapeutic phenotype and that individual SNPs may have poor predictive power as pharmacogenetic loci.
Journal ArticleDOI
Haplotype variation and linkage disequilibrium in 313 human genes.
J. Claiborne Stephens,Julie A. Schneider,Debra A. Tanguay,Julie . Choi,Tara Acharya,Scott E. Stanley,Ruhong Jiang,Chad Messer,Anne Chew,Jin-Hua Han,Jicheng Duan,Janet L. Carr,Min Seob Lee,Beena Koshy,A. Madan Kumar,Ge Zhang,William R. Newell,Andreas Windemuth,Chuanbo Xu,Theodore S. Kalbfleisch,Sandra L. Shaner,Kevin M. Arnold,Vincent P. Schulz,Connie M. Drysdale,Krishnan Nandabalan,Richard S. Judson,Gualberto Ruaño,Gerald F. Vovis +27 more
TL;DR: Pairs of SNPs exhibited variability in the degree of linkage disequilibrium that was a function of their location within a gene, distance from each other, population distribution, and population frequency.
Journal ArticleDOI
Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA
Jingyu Liu,Jingyu Liu,Godfrey D. Pearlson,Andreas Windemuth,Gualberto Ruaño,Nora I. Perrone-Bizzozero,Vince D. Calhoun +6 more
TL;DR: A framework to identify interactions between brain functional and genetic information is constructed and the findings provide a proof‐of‐concept that genomic SNP factors can be investigated by using endophenotypic imaging findings in a multivariate format.
Journal ArticleDOI
Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia
Shashwath A. Meda,Gualberto Ruaño,Andreas Windemuth,Kasey O’Neil,Clifton Berwise,Sabra M. Dunn,Leah E. Boccaccio,Balaji Narayanan,Mohan Kocherla,Emma Sprooten,Matcheri S. Keshavan,Carol A. Tamminga,John A. Sweeney,Brett A. Clementz,Vince D. Calhoun,Godfrey D. Pearlson +15 more
TL;DR: An overrepresentation of genes in major relevant pathways such as NMDA potentiation, PKA/immune response signalling, synaptogenesis, and axon guidance that influenced altered DMN connectivity in psychoses are found.
Journal ArticleDOI
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Kristine R. Crews,Andrew A. Monte,Rachel Huddart,Kelly E. Caudle,Evan D. Kharasch,Andrea Gaedigk,Andrea Gaedigk,Henry M. Dunnenberger,J. Steven Leeder,J. Steven Leeder,John T. Callaghan,Caroline Flora Samer,Teri E. Klein,Cyrine E. Haidar,Sara L. Van Driest,Gualberto Ruaño,Katrin Sangkuhl,Larisa H. Cavallari,Daniel J. Müller,Cynthia A. Prows,Mohamed Nagy,Andrew A. Somogyi,Todd C. Skaar +22 more
TL;DR: In this article, the authors provide therapeutic recommendations for the use of CYP2D6 genotype results for prescribing codeine and tramadol and describe the limited and/or weak data for CYP 2D6 and hydrocodone, oxycodone, and methadone for clinical use.