Y
Yu Lan
Researcher at Jinan University
Publications - 48
Citations - 2406
Yu Lan is an academic researcher from Jinan University. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 19, co-authored 47 publications receiving 1649 citations. Previous affiliations of Yu Lan include Academy of Military Medical Sciences.
Papers
More filters
Journal ArticleDOI
Tracing haematopoietic stem cell formation at single-cell resolution
Fan Zhou,Xianlong Li,Weili Wang,Ping Zhu,Jie Zhou,Wenyan He,Meng Ding,Fuyin Xiong,Xiaona Zheng,Zhuan Li,Yanli Ni,Xiaohuan Mu,Lu Wen,Lu Wen,Tao Cheng,Yu Lan,Weiping Yuan,Fuchou Tang,Bing Liu,Bing Liu,Bing Liu +20 more
TL;DR: In this article, the identification of mouse embryonic pre-haematopoietic stem cells at single-cell resolution is described, and a mouse embryonic stem cell was identified at single cell resolution.
Journal ArticleDOI
Deciphering human macrophage development at single-cell resolution
Zhilei Bian,Yandong Gong,Tao Huang,Christopher Z. W. Lee,Christopher Z. W. Lee,Lihong Bian,Zhijie Bai,Hui Shi,Yang Zeng,Chen Liu,Jian He,Jie Zhou,Xianlong Li,Zongcheng Li,Yanli Ni,Chunyu Ma,Lei Cui,Rui Zhang,Jerry Kok Yen Chan,Jerry Kok Yen Chan,Lai Guan Ng,Yu Lan,Florent Ginhoux,Bing Liu,Bing Liu,Bing Liu +25 more
TL;DR: The data represent a comprehensive characterization of the spatiotemporal dynamics of early macrophage development during human embryogenesis, providing a reference for future studies of the development and function of human TRMs.
Journal ArticleDOI
Endothelial Smad4 maintains cerebrovascular integrity by activating N-cadherin through cooperation with Notch.
Fangfei Li,Yu Lan,Youliang Wang,Jun Wang,Guan Yang,Fanwei Meng,Hua Han,Anming Meng,Yaping Wang,Xiao Yang +9 more
TL;DR: It is reported that disruption of Smad4, the central intracellular mediator of transforming growth factor-β (TGF-β) signaling, specifically in the cerebral ECs, results in perinatal ICH and blood-brain barrier breakdown and suggest important implications for genetic or functional deficiencies in TGF- β/Smad signaling in the pathogenesis of cerebrovascular dysfunction.
Journal ArticleDOI
Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development
Zhuan Li,Yu Lan,Wenyan He,Dong-Bo Chen,Jun Wang,Fan Zhou,Yu Wang,Huayan Sun,Xianda Chen,Chunhong Xu,Sha Li,Yakun Pang,Guangzhou Zhang,Liping Yang,Lingling Zhu,Ming Fan,Aijia Shang,Zhenyu Ju,Lingfei Luo,Yu-Qiang Ding,Wei Guo,Weiping Yuan,Xiao Yang,Bing Liu,Bing Liu,Bing Liu +25 more
TL;DR: It is concluded that the mouse embryonic head is a previously unappreciated site for HSC emergence within the developing embryo, and the physiological contribution of cerebrovascular endothelium to postnatal HSCs and multilineage hematopoiesis is revealed.