G
Guilherme Martins Santos
Researcher at University of Brasília
Publications - 20
Citations - 1124
Guilherme Martins Santos is an academic researcher from University of Brasília. The author has contributed to research in topics: Nucleosome & Histone. The author has an hindex of 11, co-authored 19 publications receiving 984 citations. Previous affiliations of Guilherme Martins Santos include Laboratory of Molecular Biology & RMIT University.
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Journal ArticleDOI
Structure of HDAC3 bound to co-repressor and inositol tetraphosphate
TL;DR: The structure of a complex between an HDAC and a co-repressor is reported, namely, human HDAC3 with the deacetylase activation domain (DAD) from the human SMRT co- Repressor (also known as NCOR2).
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ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner
Martin J. Law,Karen M. Lower,Hsiao P.J. Voon,Jim R. Hughes,David Garrick,Vip Viprakasit,Matthew Mitson,Marco De Gobbi,Marco A. Marra,Andrew J. Morris,Aaron Abbott,Steven P. Wilder,Stephen Taylor,Guilherme Martins Santos,Joe Cross,Helena Ayyub,Steven J.M. Jones,Jiannis Ragoussis,Daniela Rhodes,Ian Dunham,Douglas R. Higgs,Richard J. Gibbons +21 more
TL;DR: It is shown that ATRX binds G-quadruplex structures in vitro, suggesting a mechanism by which ATRx may play a role in various nuclear processes and how this is perturbed when ATRZ is mutated.
Journal ArticleDOI
Negative regulation by nuclear receptors: a plethora of mechanisms
TL;DR: An understanding of the mechanism for ligand-induced repression and how this differs from activation has proven elusive, and a number of recent studies have directly or indirectly addressed this problem.
Journal ArticleDOI
Tumor necrosis factor-α down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway
Valéry Afonso,Guilherme Martins Santos,Guilherme Martins Santos,Pascal Collin,Pascal Collin,Abdel-Majid Khatib,Dragoslav R. Mitrovic,Dragoslav R. Mitrovic,Noureddine Lomri,Dale C. Leitman,Abderrahim Lomri,Abderrahim Lomri +11 more
TL;DR: Overexpression of Cu/Zn superoxide dismutase 1 (SOD1) in monocytes blocks reactive oxygen species-induced inhibition of cell growth and apoptosis and renders cells resistant to the toxic effect of tumor necrosis factor (TNF)-α, suggesting that TNF-α represses the SOD1 gene in these cells.
Journal ArticleDOI
Negative Regulation of Superoxide Dismutase-1 Promoter by Thyroid Hormone
Guilherme Martins Santos,Valéry Afonso,Gustavo Barcelos Barra,Marie Togashi,Marie Togashi,Paul Webb,Francisco de Assis Rocha Neves,Noureddine Lomri,Abderrahim Lomri,Abderrahim Lomri +9 more
TL;DR: Together, the findings suggest a mechanism of negative regulation in which TR binds to the SOD-1 promoter but coactivator and corepressor binding surfaces have an inverted function, which may be important in T3 induction of oxidative stress in thyroid hormone excess.