H
Hsiao P.J. Voon
Researcher at Monash University, Clayton campus
Publications - 15
Citations - 956
Hsiao P.J. Voon is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: ATRX & Heterochromatin. The author has an hindex of 11, co-authored 13 publications receiving 759 citations. Previous affiliations of Hsiao P.J. Voon include John Radcliffe Hospital & Monash University.
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Journal ArticleDOI
ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner
Martin J. Law,Karen M. Lower,Hsiao P.J. Voon,Jim R. Hughes,David Garrick,Vip Viprakasit,Matthew Mitson,Marco De Gobbi,Marco A. Marra,Andrew J. Morris,Aaron Abbott,Steven P. Wilder,Stephen Taylor,Guilherme Martins Santos,Joe Cross,Helena Ayyub,Steven J.M. Jones,Jiannis Ragoussis,Daniela Rhodes,Ian Dunham,Douglas R. Higgs,Richard J. Gibbons +21 more
TL;DR: It is shown that ATRX binds G-quadruplex structures in vitro, suggesting a mechanism by which ATRx may play a role in various nuclear processes and how this is perturbed when ATRZ is mutated.
Journal ArticleDOI
ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.
Hsiao P.J. Voon,Jim R. Hughes,Christina Rode,Inti A. De La Rosa-Velázquez,Thomas Jenuwein,Robert Feil,Douglas R. Higgs,Richard J. Gibbons +7 more
TL;DR: A model whereby ATRX-dependent deposition of H3.3 into heterochromatin is normally required to maintain the memory of silencing at imprinted loci is proposed, which would explain the high level of aberrant allelic expression in silenced imprinted alleles in mouse ESCs.
Journal ArticleDOI
The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats
Diu T.T. Nguyen,Hsiao P.J. Voon,Hsiao P.J. Voon,Barbara Xella,Caroline Scott,David Clynes,Christian Babbs,Helena Ayyub,Jon Kerry,Jacqueline A. Sharpe,Jackie Sloane-Stanley,Sue Butler,Chris Fisher,Nicki Gray,Thomas Jenuwein,Douglas R. Higgs,Richard J. Gibbons +16 more
TL;DR: The data suggest that the presence of ATRX at telomeres may have a central role in suppressing deleterious DNA secondary structures that form at transcribed telomeric repeats, and this may account for the increased DNA damage, stalling of replication and homology‐directed repair previously observed upon loss of ATrX function.
Journal ArticleDOI
New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
Hsiao P.J. Voon,Lee H. Wong +1 more
TL;DR: An overview of the individual components tested in each study is provided and a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome is proposed.
Journal ArticleDOI
Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers.
Maheshi Udugama,Elaine Sanij,Elaine Sanij,Hsiao P.J. Voon,Jinbae Son,Linda Hii,Jeremy D. Henson,F. Lyn Chan,Fiona T. M. Chang,Yumei Liu,Richard B. Pearson,Richard B. Pearson,Richard B. Pearson,Paul Kalitsis,Jeffrey R. Mann,Philippe Collas,Philippe Collas,Ross D. Hannan,Lee H. Wong +18 more
TL;DR: This study provides insights into the contribution of ATRX loss of function to tumorigenesis through the loss of rDNA stability and suggests the therapeutic potential of targeting Pol I transcription in ALT cancers.