Guoqing Hou

TL;DR: Administration of vorinostat in combination with standard GVHD prophylaxis after related-donor reduced-intensity conditioning haemopoietic stem-cell transplantation is safe and is associated with a lower than expected incidence of severe acute GV HD.

TL;DR: It is demonstrated that HDAC inhibition reduces inflammatory responses of PBMC but enhances Tregs after allo-HCT, andHDAC inhibition also increased signal transducer and activator of transcription 3 acetylation and induced indoleamine-2,3-dioxygenase.

TL;DR: It is reported that Siglec-G expression on host APCs, specifically on hematopoietic cells, negatively regulates GVHD in multiple clinically relevant murine models and suggested that enhancing this interaction may represent a novel strategy for mitigating GV HD.

TL;DR: Inhibition of neddylation suppressed the release of proinflammatory cytokines by DCs in response to Toll-like receptor, nucleotide oligomerization domain- like receptor, and noninfectious CD40L stimulation, and could be a novel strategy for mitigating immune-mediated disease processes.

TL;DR: The hypothesis that HDAC inhibition will be safe and reduce the severity of GVHD in patients undergoing matched related donor (MRD) reduced intensity conditioning (RIC) allogeneic HSCT is tested in a first-in-human clinical trial.