G
Guoshun He
Researcher at Howard Hughes Medical Institute
Publications - 2
Citations - 232
Guoshun He is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Identification (biology) & Protein Data Bank. The author has an hindex of 2, co-authored 2 publications receiving 224 citations. Previous affiliations of Guoshun He include Rockefeller University.
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Journal ArticleDOI
Structural genomics: A pipeline for providing structures for the biologist
Mark R. Chance,Anne R. Bresnick,Stephen K. Burley,Stephen K. Burley,Jiansheng Jiang,Christopher D. Lima,Andrej Sali,Steven C. Almo,Jeffrey B. Bonanno,John A. Buglino,Simon J. Boulton,Hua Chen,Hua Chen,Narayanan Eswar,Guoshun He,Guoshun He,Raymond Y. Huang,Valentin A. Ilyin,Linda McMahan,Ursula Pieper,Soumya S. Ray,Marc Vidal,Li Kai Wang +22 more
TL;DR: Structural biologists have embraced high-throughput biology by developing and implementing technologies that will enable the structures of hundreds of protein domains to be solved in a relatively short time.
Journal ArticleDOI
Cocrystal Structures of Diaminopimelate Decarboxylase: Mechanism, Evolution, and Inhibition of an Antibiotic Resistance Accessory Factor
Soumya S. Ray,Jeffrey B. Bonanno,Jeffrey B. Bonanno,K.R. Rajashankar,Mariana G. Pinho,Guoshun He,Guoshun He,Hermínia de Lencastre,Alexander Tomasz,Stephen K. Burley,Stephen K. Burley +10 more
TL;DR: Cocrystal structures of Methanococcus jannaschii diaminopimelate decarboxylase (DAPDC) bound to a substrate analog, azelaic acid, and its L-lysine product have been determined and implications for rational design of broad-spectrum antimicrobial agents targeted against DAPDCs of drug-resistant strains of bacterial pathogens are discussed.