Guy Boileau

TL;DR: Babies with the infantile form of HPP often die with severe rickets and sometimes hypercalcemia and vitamin B6‐dependent seizures.

TL;DR: It is demonstrated that Pex mRNA is expressed in bones and teeth and suggests that this putative endopeptidase plays an important role in the development of these tissues.

TL;DR: It is demonstrated that NEP can inhibit FAK phosphorylation on tyrosine and PC cell migration through multiple pathways and suggest that cell migration which contributes to invasion and metastases in PC cells can be regulated by NEP.

TL;DR: The results are consistent with the hypothesis that loss of Phex function affects the mineralizing activity of osteoblasts rather than their differentiation, and suggest a correlation between Phex expression and bone formation.

TL;DR: An expression vector is constructed in which the rabbit kidney cDNA encoding the entire neutral endopeptidase sequence is introduced downstream from the SV40 virus early promotor, which identifies Glu-584 as one of the important residues responsible for the catalytic activity of the enzyme.