H
Hagit Shapiro
Researcher at Weizmann Institute of Science
Publications - 36
Citations - 9311
Hagit Shapiro is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 22, co-authored 27 publications receiving 6142 citations.
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Journal ArticleDOI
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Jotham Suez,Tal Korem,David Zeevi,Gili Zilberman-Schapira,Christoph A. Thaiss,Ori Maza,David Israeli,Niv Zmora,Shlomit Gilad,Adina Weinberger,Yael Kuperman,Alon Harmelin,Ilana Kolodkin-Gal,Hagit Shapiro,Zamir Halpern,Eran Segal,Eran Elinav +16 more
TL;DR: It is demonstrated that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota, thereby calling for a reassessment of massive NAS usage.
Journal ArticleDOI
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
Journal ArticleDOI
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Christoph A. Thaiss,David Zeevi,Maayan Levy,Gili Zilberman-Schapira,Jotham Suez,Anouk C. Tengeler,Lior Abramson,Meirav Katz,Meirav Katz,Tal Korem,Niv Zmora,Yael Kuperman,Inbal E. Biton,Shlomit Gilad,Alon Harmelin,Hagit Shapiro,Zamir Halpern,Eran Segal,Eran Elinav +18 more
TL;DR: Evidence of coordinated metaorganism diurnal rhythmicity is provided and jet-lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation.
Journal ArticleDOI
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
Maayan Levy,Christoph A. Thaiss,David Zeevi,Lenka Dohnalová,Gili Zilberman-Schapira,Jemal Ali Mahdi,Eyal David,Alon Savidor,Tal Korem,Yonatan Herzig,Meirav Pevsner-Fischer,Hagit Shapiro,Anette Christ,Alon Harmelin,Zamir Halpern,Eicke Latz,Eicke Latz,Richard A. Flavell,Ido Amit,Eran Segal,Eran Elinav +20 more
TL;DR: It is demonstrated that the microbiota-associated metabolites taurine, histamine, and spermine shape the host-microbiome interface by co-modulating NLRP6 inflammasome signaling, epithelial IL-18 secretion, and downstream anti-microbial peptide (AMP) profiles.
Journal ArticleDOI
Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT.
Jotham Suez,Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Max Horn,Yotam Cohen,Andreas E. Moor,David Zeevi,Tal Korem,Eran Kotler,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Meirav Pevsner-Fischer,Hagit Shapiro,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: Collectively, potential post-antibiotic probiotic benefits may be offset by a compromised gut mucosal recovery, highlighting a need of developing aFMT or personalized probiotic approaches achieving mucosal protection without compromising microbiome recolonization in the antibiotics-perturbed host.