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Guoji Guo
Researcher at Zhejiang University
Publications - 85
Citations - 8741
Guoji Guo is an academic researcher from Zhejiang University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 33, co-authored 65 publications receiving 6154 citations. Previous affiliations of Guoji Guo include Boston Children's Hospital & Genome Institute of Singapore.
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Journal ArticleDOI
Mapping the Mouse Cell Atlas by Microwell-Seq
Xiaoping Han,Renying Wang,Yincong Zhou,Lijiang Fei,Huiyu Sun,Shujing Lai,Assieh Saadatpour,Ziming Zhou,Haide Chen,Fang Ye,Daosheng Huang,Yang Xu,Wentao Huang,Mengmeng Jiang,Xinyi Jiang,Jie Mao,Yao Chen,Chenyu Lu,Jin Xie,Qun Fang,Yibin Wang,Rui Yue,Tiefeng Li,He Huang,Stuart H. Orkin,Guo-Cheng Yuan,Ming Chen,Guoji Guo +27 more
TL;DR: This study developed Microwell-seq, a high-throughput and low-cost scRNA-seq platform using simple, inexpensive devices, and built a web-based "single-cell MCA analysis" pipeline that accurately defines cell types based on single-cell digital expression.
Journal ArticleDOI
Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst
Guoji Guo,Mikael Huss,Guo Qing Tong,Chaoyang Wang,Li Li Sun,Neil D. Clarke,Paul Robson,Paul Robson +7 more
TL;DR: It is shown that in the morula, blastomeres coexpress transcription factors specific to different lineages, but by the 64-cell stage three cell types can be clearly distinguished according to their quantitative expression profiles.
Journal ArticleDOI
Construction of a human cell landscape at single-cell level.
Xiaoping Han,Ziming Zhou,Lijiang Fei,Huiyu Sun,Renying Wang,Yao Chen,Haide Chen,Jingjing Wang,Huanna Tang,Wenhao Ge,Yincong Zhou,Fang Ye,Mengmeng Jiang,Junqing Wu,Yanyu Xiao,Xiaoning Jia,Tingyue Zhang,Xiaojie Ma,Qi Zhang,Xueli Bai,Shujing Lai,Chengxuan Yu,Lijun Zhu,Rui Lin,Yuchi Gao,Min Wang,Yiqing Wu,Jianming Zhang,Renya Zhan,Saiyong Zhu,Hailan Hu,Changchun Wang,Ming Chen,He Huang,Tingbo Liang,Jianghua Chen,Weilin Wang,Dan Zhang,Guoji Guo +38 more
TL;DR: The results provide a useful resource for the study of human biology and find that stem and progenitor cells exhibit strong transcriptomic stochasticity, whereas differentiated cells are more distinct.
Journal ArticleDOI
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
Semir Beyaz,Semir Beyaz,Miyeko D. Mana,Jatin Roper,Jatin Roper,Dmitriy Kedrin,Dmitriy Kedrin,Assieh Saadatpour,Sue Jean Hong,Khristian E. Bauer-Rowe,Michael E. Xifaras,Adam Akkad,Erika Arias,Luca Pinello,Yarden Katz,Shweta Shinagare,Monther Abu-Remaileh,Maria M. Mihaylova,Dudley W. Lamming,Rizkullah Dogum,Guoji Guo,George W. Bell,Martin K. Selig,G. Petur Nielsen,Nitin K. Gupta,Cristina R. Ferrone,Vikram Deshpande,Guo-Cheng Yuan,Stuart H. Orkin,David M. Sabatini,David M. Sabatini,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz +33 more
TL;DR: It is shown that high-fat diet (HFD)-induced obesity augments the numbers and function of Lgr5+ intestinal stem cells of the mammalian intestine and highlights how diet-modulated PPAR-δ activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumours.
Journal ArticleDOI
Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
Amy Ralston,Brian J. Cox,Noriyuki Nishioka,Hiroshi Sasaki,Evelyn Chea,Peter J. Rugg-Gunn,Guoji Guo,Paul Robson,Jonathan S. Draper,Janet Rossant +9 more
TL;DR: It is suggested that Gata3 and Cdx2 can act in parallel pathways downstream of Tead4 to induce the expression of common and independent targets in the trophoblast lineage, whereas Oct4 is required for continued repression of trophOBlast fate in the embryonic lineage.