H
Harinath Kasiganesan
Researcher at Medical University of South Carolina
Publications - 27
Citations - 1081
Harinath Kasiganesan is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Pressure overload & Muscle hypertrophy. The author has an hindex of 19, co-authored 27 publications receiving 925 citations. Previous affiliations of Harinath Kasiganesan include Sewanee: The University of the South.
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Journal ArticleDOI
Ceramide synthase 5 mediates lipid-induced autophagy and hypertrophy in cardiomyocytes
Sarah Brice Russo,Catalin F. Baicu,An O. Van Laer,Tuoyu Geng,Harinath Kasiganesan,Michael R. Zile,L. Ashley Cowart +6 more
TL;DR: A requirement for a specific sphingolipid metabolic route and dietary SFAs in the molecular pathogenesis of lipotoxic cardiomyopathy and hypertrophy is revealed.
Journal ArticleDOI
Mutations in DCHS1 cause mitral valve prolapse
Ronen Durst,Ronen Durst,Kimberly Sauls,David S. Peal,Annemarieke DeVlaming,Katelynn Toomer,Maire Leyne,Monica Salani,Michael E. Talkowski,Harrison Brand,Maelle Perrocheau,Charles Simpson,Christopher Jett,Matthew R. Stone,Florie A. Charles,Colby Chiang,Stacey N. Lynch,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Francesca N. Delling,Lisa A. Freed,Christophe Tribouilloy,Thierry Le Tourneau,Herve LeMarec,Leticia Fernández-Friera,Jorge Solis,Daniel Trujillano,Stephan Ossowski,Xavier Estivill,Christian Dina,Patrick Bruneval,Adrian H. Chester,Jean-Jacques Schott,Kenneth D. Irvine,Yaopan Mao,Andy Wessels,Tahirali Motiwala,Michel Pucéat,Yoshikazu Tsukasaki,Donald R. Menick,Harinath Kasiganesan,Xingju Nie,Ann-Marie Broome,Katherine Williams,Amanda J. Johnson,Roger R. Markwald,Xavier Jeunemaitre,Xavier Jeunemaitre,Xavier Jeunemaitre,Albert Hagège,Albert Hagège,Robert A. Levine,Robert A. Levine,David J. Milan,Russell A. Norris,Susan A. Slaugenhaupt +55 more
TL;DR: A missense mutation in the DCHS1 gene, the human homologue of the Drosophila cell polarity gene dachsous (ds), that segregates with MVP in the family is reported, supporting these processes as aetiological underpinnings for the disease.
Journal ArticleDOI
HDACs Regulate miR-133a Expression in Pressure Overload–Induced Cardiac Fibrosis
Ludivine Renaud,Lillianne G. Harris,Santhosh K. Mani,Harinath Kasiganesan,James C. Chou,Catalin F. Baicu,An O. Van Laer,Adam W. Akerman,Robert E. Stroud,Jeffrey A. Jones,Michael R. Zile,Donald R. Menick +11 more
TL;DR: This work is the first to provide insight into an epigenetic-miRNA regulatory pathway in pressure overload–induced cardiac fibrosis by revealing that HDACs play a role in the regulation of pressure overload-induced miR-133a downregulation.
Journal ArticleDOI
β3 Integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy
Rebecca K. Johnston,Sundaravadivel Balasubramanian,Harinath Kasiganesan,Catalin F. Baicu,Michael R. Zile,Michael R. Zile,Dhandapani Kuppuswamy,Dhandapani Kuppuswamy +7 more
TL;DR: In this article, the role of integrins upstream of Ub and whether enhanced Ub contributes to survival signaling in early pressure overload (PO) hypertrophy near intercalated discs of cardiomyocytes, where integrin is important for mechanotransduction.
Journal ArticleDOI
Modulatory effects of seabuckthorn (Hippophae rhamnoides L.) in hypobaric hypoxia induced cerebral vascular injury
Jayamurthy Purushothaman,Geetha Suryakumar,Dhananjay Shukla,Anand Swaroop Malhotra,Harinath Kasiganesan,Ratan Kumar,R. C. Sawhney,Arumughan Chami +7 more
TL;DR: Observations suggest that SBT seed oil possesses significant hypoxia protection activity and curtailed Hypoxia induced enhanced vascular leakage in the brain.