Hartmut Schmidt

TL;DR: It is shown that short-term synaptic depression is enhanced in Bassoon knockout mice during sustained high-frequency trains but basal synaptic transmission is unaffected, and the cytomatrix protein Bassoon speeds the reloading of vesicles to release sites at a central excitatory synapse.

TL;DR: Numerical simulations imply that the effect of uncharacterised endogenous Ca2+ binding proteins is negligible, that buffered diffusion and dye saturation significantly affects spineous Ca2- transients but not those in the dendritic shafts, and that neither CB nor PV undergoes saturation in spines or dendrites during climbing fibre‐evoked Ca 2+ transients.

TL;DR: It is shown that CB interacts with IMPase in cerebellar Purkinje neurons, a cell type well known to rely on inositol-1,4,5-trisphosphate-dependent synaptic integration.

TL;DR: CB serves a threefold function as buffer, transporter and likely as a non-canonical sensor in the vertebrate central nervous system, including important projection neurons like cerebellar Purkinje cells but also neocortical interneurons.

TL;DR: The results suggest that nanodomain coupling is a general characteristic of conventional cortical synapses involved in high-frequency transmission, allowing for dense gray matter packing and cost-effective neurotransmission.