Stefan Hallermann

TL;DR: The function of Bruchpilot seems responsible for effectively clustering Ca2+ channels beneath the T-bar density late in a protracted AZ formation process, potentially through a direct molecular interaction with intracellular Ca 2+ channel domains.

TL;DR: Voltage fluctuations attributable to stochastic Ih channel gating impact on action potential output, with greater spike-timing precision in models with the experimentally determined single-channel conductance are demonstrated.

TL;DR: New approaches to quantify endogenous protein organization at single-molecule resolution in situ with super-resolution imaging by direct stochastic optical reconstruction microscopy (dSTORM) are introduced and indicate that the precise nanoscopic organization of Brp distinguishes different physiological AZ states and link functional diversification to a heretofore unrecognized neuronal gradient of the CAZ ultrastructure.

TL;DR: It is shown that an activity-dependent, site-specific control of GluR composition can contribute to match pre- and postsynaptic assembly.

TL;DR: It is shown that short-term synaptic depression is enhanced in Bassoon knockout mice during sustained high-frequency trains but basal synaptic transmission is unaffected, and the cytomatrix protein Bassoon speeds the reloading of vesicles to release sites at a central excitatory synapse.