H
Heide-Marie Binder
Researcher at Paracelsus Private Medical University of Salzburg
Publications - 8
Citations - 93
Heide-Marie Binder is an academic researcher from Paracelsus Private Medical University of Salzburg. The author has contributed to research in topics: Epidermolysis bullosa & Flow cytometry. The author has an hindex of 3, co-authored 5 publications receiving 13 citations.
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Journal ArticleDOI
A functional corona around extracellular vesicles enhances angiogenesis, skin regeneration and immunomodulation
Martin Wolf,Rodolphe Poupardin,Patricia Ebner-Peking,André Cronemberger Andrade,C. Blöchl,Astrid Obermayer,Fausto Gueths Gomes,Balazs Vari,Nicole Maeding,Essi Eminger,Heide-Marie Binder,Anna M. Raninger,Sarah Hochmann,Gabriele Brachtl,Andreas Spittler,Thomas Heuser,Racheli Ofir,Christian G. Huber,Zami Aberman,Katharina Schallmoser,Hans-Dieter Volk,Dirk Strunk +21 more
TL;DR: It is demonstrated that nano‐sized EVs from therapy‐grade human placental‐expanded (PLX) stromal cells are surrounded by an imageable and functional protein corona when enriched with permissive technology.
Journal ArticleDOI
Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles.
André Cronemberger Andrade,Martin Wolf,Heide-Marie Binder,Fausto Gueths Gomes,Felix Manstein,Patricia Ebner-Peking,Rodolphe Poupardin,Robert Zweigerdt,Katharina Schallmoser,Dirk Strunk +9 more
TL;DR: In this paper, the authors investigated the effect of hypoxia on extracellular vesicles (EVs) in human induced pluripotent stem cells (iPSC) culture.
Journal ArticleDOI
A non-viral and selection-free COL7A1 HDR approach with improved safety profile for dystrophic epidermolysis bullosa.
Thomas Kocher,Johannes Bischof,Simone A. Haas,Oliver Patrick March,Bernadette Liemberger,Stefan Hainzl,Julia Illmer,Anna Hoog,Katharina Muigg,Heide-Marie Binder,Alfred Klausegger,Dirk Strunk,Johann W. Bauer,Toni Cathomen,Ulrich Koller +14 more
TL;DR: Detailed on- and off-target analyses confirmed that the combined treatment of paired nicking and single-stranded oligonucleotides constituted a highly efficient COL7A1 editing strategy, associated with a significantly improved safety profile, and represent a further advancement in the field of traceless genome editing for genodermatoses.
Journal ArticleDOI
Paired nicking-mediated COL17A1 reframing for junctional epidermolysis bullosa.
Johannes Bischof,Oliver Patrick March,Bernadette Liemberger,Simone A. Haas,Stefan Hainzl,Igor Petkovic,Victoria M. Leb-Reichl,J. Illmer,Evgeniia Korotchenko,Alfred Klausegger,Anna Maria Hoog,Heide-Marie Binder,Marta Robles García,Blanca Duarte,Dirk Strunk,Fernando Larcher,Julia Reichelt,Christina Guttmann-Gruber,Verena Wally,Josefina Piñón Hofbauer,Johann W. Bauer,Toni Cathomen,Thomas Kocher,Ulrich Koller +23 more
TL;DR: Kocher et al. as discussed by the authors designed patient-specific Cas9-nuclease-and-nickase-based targeting strategies for reframing a common homozygous deletion in exon 52 of COL17A1 associated with a lack of full-length C17 expression.
Posted ContentDOI
Extracellular vesicles from therapeutic grade allogeneic human placental stromal cells induce angiogenesis and modulate immunity
Martin Wolf,Balazs Vari,Constantin Blöchl,Anna M. Raninger,Rodolphe Poupardin,Cristien M Beez,Anna Hoog,Gabi Brachtl,Essi Eminger,Heide-Marie Binder,Michaela Oeller,Andreas Spittler,Thomas Heuser,Astrid Obermayer,Martina Seifert,Christian G. Huber,Katharina Schallmoser,Hans-Dieter Volk,Dirk Strunk +18 more
TL;DR: Evidence is provided that EVs derived from therapeutic placental-expanded (PLX) stromal cells are potent inducers of angiogenesis and modulate immune cell proliferation in a dose-dependent manner, and indicates that the mode of PLX action involves an EV-mediated proangiogenic function and immune response modulation.