D
D W Crook
Researcher at University of Oxford
Publications - 23
Citations - 2212
D W Crook is an academic researcher from University of Oxford. The author has contributed to research in topics: Neutralization & Tuberculosis. The author has an hindex of 7, co-authored 23 publications receiving 1007 citations. Previous affiliations of D W Crook include Public Health England & National Institute for Health Research.
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Journal ArticleDOI
Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers.
Sheila F Lumley,Denise O'Donnell,Nicole Stoesser,Philippa C Matthews,Alison Howarth,Stephanie B Hatch,Brian D. Marsden,Stuart Cox,Tim James,Fiona Warren,Liam J Peck,Thomas G Ritter,Z de Toledo,Laura Warren,David Axten,Richard J. Cornall,E Y Jones,David I. Stuart,Gavin R. Screaton,Daniel Ebner,Sarah Hoosdally,Sarah Hoosdally,Meera Chand,D W Crook,D W Crook,O'Donnell A-M.,Christopher P. Conlon,Koen B. Pouwels,A S Walker,A S Walker,Peto Tea.,Susan Hopkins,Timothy M Walker,Katie Jeffery,David W Eyre +34 more
TL;DR: The relationship between the presence of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the risk of subsequent reinfection remains unclear as discussed by the authors.
Journal ArticleDOI
Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum.
Chang Liu,Helen M. Ginn,Wanwisa Dejnirattisai,P Supasa,Beibei Wang,Aekkachai Tuekprakhon,R Nutalai,D. Zhou,Alexander J. Mentzer,Yuguang Zhao,Duyvesteyn Hme.,Cesar Lopez-Camacho,J Slon-Campos,Thomas S. Walter,Donal T. Skelly,S A Johnson,T G Ritter,C Mason,S A Costa Clemens,F. Gomes Naveca,Valdinete Alves do Nascimento,Fabrícia F. Nascimento,C Fernandes da Costa,Paola Cristina Resende,Alex Pauvolid-Corrêa,Marilda M. Siqueira,Christina Dold,Nigel J. Temperton,Tao Dong,Andrew J. Pollard,James C. Knight,D W Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,T Malik,Miles W. Carroll,Paul Klenerman,Eleanor Barnes,Susanna Dunachie,Vicky L. Baillie,Vicky L. Baillie,N Serafin,N Serafin,Z Ditse,Z Ditse,K Da Silva,K Da Silva,Neil G. Paterson,Mark A. Williams,David Hall,Shabir A. Madhi,Shabir A. Madhi,M C Nunes,M C Nunes,P Goulder,Elizabeth E. Fry,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +65 more
TL;DR: In this paper, the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.617.1 and B.1.2 has been studied.
Journal ArticleDOI
Antibody evasion by the P.1 strain of SARS-CoV-2.
Wanwisa Dejnirattisai,D. Zhou,P Supasa,Chang Liu,Alexander J. Mentzer,Helen M. Ginn,Yuguang Zhao,Duyvesteyn Hme.,Aekkachai Tuekprakhon,R Nutalai,Beibei Wang,Cesar Lopez-Camacho,J Slon-Campos,Thomas S. Walter,Donal T. Skelly,S A Costa Clemens,Felipe Gomes Naveca,Valdinete Alves do Nascimento,Fabrícia F. Nascimento,C Fernandes da Costa,Paola Cristina Resende,Alex Pauvolid-Corrêa,Marilda M. Siqueira,Christina Dold,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,D W Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,Miles W. Carroll,Paul Klenerman,E Barnes,Susanna Dunachie,Neil G. Paterson,Mark A. Williams,David R. Hall,Hulswit Rjg.,Thomas A. Bowden,Elizabeth E. Fry,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +50 more
TL;DR: In this paper, structural analysis of the ACE2 binding sites of the SARS-CoV-2 pandemic strain has been carried out and the authors show that the 222 light chain is able to largely restore neutralization potency to a major class of public antibodies.
Journal ArticleDOI
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
P Supasa,D. Zhou,Wanwisa Dejnirattisai,Chang Liu,Alexander J. Mentzer,Helen M. Ginn,Yuguang Zhao,Duyvesteyn Hme.,R Nutalai,Aekkachai Tuekprakhon,Beibei Wang,Guido C. Paesen,J Slon-Campos,Cesar Lopez-Camacho,Bassam Hallis,Naomi Coombes,Kevin R. Bewley,Sue Charlton,Thomas S. Walter,Eleanor Barnes,Susanna Dunachie,Donal T. Skelly,Sheila F Lumley,Natalie Baker,I Shaik,Holly E. Humphries,Kerry J Godwin,N Gent,A Sienkiewicz,Christina Dold,R Levin,Tao Dong,Andrew J. Pollard,Julian C. Knight,Paul Klenerman,D W Crook,Teresa Lambe,Elizabeth A. Clutterbuck,S Bibi,Amy Flaxman,M Bittaye,Sandra Belij-Rammerstorfer,Sarah C. Gilbert,David R. Hall,Mark A. Williams,Neil G. Paterson,William James,Miles W. Carroll,Elizabeth E. Fry,Juthathip Mongkolsapaya,Jingshan Ren,David I. Stuart,Gavin R. Screaton +52 more
TL;DR: In this article, the authors examined the ability of B.1.7 to evade antibody responses elicited by natural SARS-CoV-2 infection or vaccination, and found that B. 1.7 is harder to neutralize than parental virus, compromising neutralization by some members of a major class of public antibodies through light chain contacts with residue 501.
Posted ContentDOI
Amplicon based MinION sequencing of SARS-CoV-2 and metagenomic characterisation of nasopharyngeal swabs from patients with COVID-19
Shona C Moore,Rebekah Penrice-Randal,Muhannad Alruwaili,Xiaofeng Dong,Steven T. Pullan,Daniel P. Carter,Kevin R. Bewley,Qin Zhao,Qin Zhao,Yani Sun,Yani Sun,Catherine Hartley,En-Min Zhou,En-Min Zhou,Tom Solomon,Michael Beadsworth,James Cruise,Debby Bogaert,D W Crook,David A. Matthews,Andrew D. Davidson,Zana H. Mahmood,Waleed Aljabr,Julian Druce,Richard Vipond,Lisa Ng,Laurent Rénia,Peter J. M. Openshaw,J Kenneth Baillie,Miles W. Carroll,Calum Semple,Lance Turtle,Julian A. Hiscox +32 more
TL;DR: Amplicon and metagenomic MinION based sequencing was used to rapidly identify SARS-CoV-2 and assess the microbiome in nasopharyngeal swabs obtained from patients with COVID-19 by the ISARIC 4C consortium.