Helmut Brade

TL;DR: It was found that synthetic and natural free lipid A exhibit identical activities and are indistinguishable in all tests.

TL;DR: The results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury and agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation.

TL;DR: Biological analysis of synthetic lipid A partial structures proved that the expression of endotoxic activity depends on a unique structural arrangement and conformation and analyses have provided insight into the determinants required for lipid A binding to and activation of human target cells.

TL;DR: These experiments provide the first direct evidence that death in a mouse typhoid infection is directly dependent on the toxicity of lipid A and suggest that this may be mediated via pro‐inflammatory cytokine and inducible nitric oxide synthase responses both in vivo and in vitro.

TL;DR: The presence of LPS in the bloodstream, as observed during severe Gram-negative, bacterial infections or possibly caused by translocation of enterobacteria from the gut, leads to various pathophysiological reactions such as fever, leukopenia, tachypnoea, hypotension, disseminated intravascular coagulation.