Hema Vasavada

TL;DR: The existence of a non-canonical cortical NOTCH1 signalling pathway that regulates vascular barrier function is established, and thus provides a mechanism by which a single receptor might link transcriptional programs with adhesive and cytoskeletal remodelling.

TL;DR: In developing bone marrow, the vasculature can sustain multilineage progenitors, but interactions with osteolineage cells are needed to regulate long-term HSC proliferation and potential, and the timing of murine fetal long bone vascularization and ossification relative to the onset of HSC activity is established.

TL;DR: This work found that re-expression of c-Kit in RA-deficient (Raldh2(-/-)) primordial endothelium induced Notch signaling and p27 expression, which restored cell-cycle control and rescued hemogenic endothelial cell specification and function.

TL;DR: In this paper, the authors identify Rac2 as a major inflammatory regulator of signaling that directs plaque osteogenesis, and they found that elevated IL-1β was an independent predictor of cardiovascular death in those subjects with high coronary calcium burden.

TL;DR: The expression ofVEGF dampens the expression of microRNA-1, which drives inflammation in part via increasing theexpression of Mpl.VEGF.