Hendrik Streeck

TL;DR: In this article, an unbiased antibody profiling approach was used to show that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, such that Ltb infection is associated with unique Ab Fc functional profiles, selective binding to FcγRIII, and distinct Ab glycosylation patterns.

TL;DR: It is shown that individuals with latent tuberculosis infection (Ltb) and active tuberculosis disease (Atb) have distinct Mtb-specific humoral responses, which point to a potential role for Fc-mediated Ab effector functions, tuned via differential glycosylation, in Mtb control.

TL;DR: The importance of sex-dependent differences in vaccine-induced immunity is highlighted and the role of sex as a modulator of humoral immunity, key to long-term pathogen-specific protection is addressed.

TL;DR: The optimized bead-based, antigen-specific assay represents a simple, highly adaptable platform to profile antibody-dependent complement activation across pathogens and diseases.

TL;DR: The landscape of effector cells and Fc receptors present within vulnerable tissues is defined and non-ADCC-mediated mechanisms, such as phagocytosis and neutrophil activation, are more likely to play a role in preventative vaccine or reservoir-eliminating therapeutic approaches.