C
Carolyn M. Boudreau
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 8
Citations - 840
Carolyn M. Boudreau is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Vaccination & Antibody. The author has an hindex of 5, co-authored 6 publications receiving 415 citations. Previous affiliations of Carolyn M. Boudreau include Massachusetts Institute of Technology & Harvard University.
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Journal ArticleDOI
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans.
Thomas Hagan,Mario Cortese,Nadine Rouphael,Carolyn M. Boudreau,Caitlin Linde,Mohan S. Maddur,Jishnu Das,Hong Wang,Jenna J. Guthmiller,Nai-Ying Zheng,Min Huang,Amit A. Uphadhyay,Luiz Gustavo Gardinassi,Caroline Petitdemange,Michele Paine McCullough,Sara Jo Johnson,Kiran Gill,Barbara Cervasi,Jun Zou,Alexis Bretin,Megan Hahn,Andrew T. Gewirtz,Steve E. Bosinger,Patrick C. Wilson,Shuzhao Li,Galit Alter,Surender Khurana,Hana Golding,Bali Pulendran +28 more
TL;DR: Antibiotics treatment prior and subsequent to seasonal influenza vaccination revealed significant associations between bacterial species and metabolic phenotypes, highlighting a key role for the microbiome in modulating human immunity.
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Sex differences in vaccine-induced humoral immunity.
TL;DR: The importance of sex-dependent differences in vaccine-induced immunity is highlighted and the role of sex as a modulator of humoral immunity, key to long-term pathogen-specific protection is addressed.
Journal ArticleDOI
Fc Glycan-Mediated Regulation of Placental Antibody Transfer
Madeleine F. Jennewein,Ilona T. Goldfarb,Sepideh Dolatshahi,Sepideh Dolatshahi,Cormac Cosgrove,Francesca Fj Noelette,Marina Krykbaeva,Jishnu Das,Jishnu Das,Aniruddh Sarkar,Aniruddh Sarkar,Matthew J. Gorman,Stephanie Fischinger,Carolyn M. Boudreau,Joelle Brown,Jennifer H. Cooperrider,Jasneet Aneja,Todd J. Suscovich,Barney S. Graham,Georg M. Lauer,Tessa Goetghebuer,Arnaud Marchant,Douglas A. Lauffenburger,Arthur Y. Kim,Laura E. Riley,Galit Alter +25 more
TL;DR: Insight is provided for the development of next-generation maternal vaccines designed to elicit antibodies that will most effectively aid neonates by using systems serology to define Fc features associated with antibody transfer.
Journal ArticleDOI
Extra-Neutralizing FcR-Mediated Antibody Functions for a Universal Influenza Vaccine.
Carolyn M. Boudreau,Galit Alter +1 more
TL;DR: The data related to Fc-effector functional protection from influenza is reviewed and prospects to leverage this humoral immune activity for the development of a universal influenza vaccine are discussed.
Journal ArticleDOI
Outflanking immunodominance to target subdominant broadly neutralizing epitopes.
Davide Angeletti,Davide Angeletti,Ivan Kosik,Jefferson J.S. Santos,William T. Yewdell,Carolyn M. Boudreau,Carolyn M. Boudreau,Vamsee Mallajosyula,Madeleine C. Mankowski,Michael Chambers,Madhu Prabhakaran,Heather D. Hickman,Adrian B. McDermott,Galit Alter,Jayanta Chaudhuri,Jonathan W. Yewdell +15 more
TL;DR: This work has immunized mice with full-length HA and HA stem alone or in different combinations and shown that physical attachment of HA head to stem severely hinders stem responses, and delineate strategies for overcoming immunodominance.