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Ashlin R. Michell
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 13
Citations - 1025
Ashlin R. Michell is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Medicine & Malaria vaccine. The author has an hindex of 6, co-authored 9 publications receiving 476 citations.
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Journal ArticleDOI
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
Compromised SARS-CoV-2-specific placental antibody transfer.
Caroline Atyeo,Caroline Atyeo,Krista M. Pullen,Evan A. Bordt,Stephanie Fischinger,Stephanie Fischinger,John F. Burke,Ashlin R. Michell,Matthew D. Slein,Carolin Loos,Carolin Loos,Lydia L. Shook,Adeline A. Boatin,Laura J. Yockey,David Pépin,Marie-Charlotte Meinsohn,Ngoc Minh Phuong Nguyen,Maeva Chauvin,Drucilla J. Roberts,Ilona T. Goldfarb,Juan D. Matute,Kaitlyn E. James,Lael M. Yonker,Lisa M. Bebell,Anjali J Kaimal,Kathryn J. Gray,Douglas A. Lauffenburger,Andrea G. Edlow,Galit Alter +28 more
TL;DR: Systems serology characterized the Fc-profile of influenza, pertussis, and SARS-CoV-2-specific antibodies transferred across the placenta to point to unexpected compensatory mechanisms to boost immunity in neonates, providing insights for maternal vaccine design.
Journal ArticleDOI
A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation.
Stephanie Fischinger,Jonathan K. Fallon,Ashlin R. Michell,Thomas Broge,Todd J. Suscovich,Hendrik Streeck,Galit Alter +6 more
TL;DR: The optimized bead-based, antigen-specific assay represents a simple, highly adaptable platform to profile antibody-dependent complement activation across pathogens and diseases.
Journal ArticleDOI
Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination
Todd J. Suscovich,Jonathan K. Fallon,Jishnu Das,Allison Demas,Allison Demas,Jonathan Crain,Caitlyn Linde,Ashlin R. Michell,Harini Natarajan,Claudia Arevalo,Thomas Broge,Thomas C. Linnekin,Viraj Kulkarni,Richard Lu,Matthew D. Slein,Corinne Luedemann,Meghan Marquette,Sandra March,Joshua A. Weiner,Scott Gregory,Margherita Coccia,Yevel Flores-Garcia,Fidel Zavala,Margaret E. Ackerman,Elke S. Bergmann-Leitner,Jenny Hendriks,Jerald C. Sadoff,Sheetij Dutta,Sangeeta N. Bhatia,Douglas A. Lauffenburger,Erik Jongert,Ulrike Wille-Reece,Galit Alter +32 more
TL;DR: Functional validation using monoclonal antibodies confirmed the protective role of Fc-mediated antibody functions in restricting parasite infection both in vitro and in vivo, suggesting that these correlates may mechanistically contribute to parasite restriction and can be used to guide the rational design of an improved vaccine against malaria.
Journal ArticleDOI
Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination.
Angela M. Minassian,Sarah E. Silk,Jordan R. Barrett,Carolyn M. Nielsen,Kazutoyo Miura,Ababacar Diouf,Carolin Loos,Carolin Loos,Jonathan K. Fallon,Ashlin R. Michell,Michael T. White,Nick J. Edwards,Ian D. Poulton,Celia Mitton,Ruth O. Payne,Michael Marks,Hector Maxwell-Scott,Antonio Querol-Rubiera,Karen Bisnauthsing,Rahul Batra,Tatiana Ogrina,Nathan J Brendish,Yrene Themistocleous,Thomas A. Rawlinson,Katherine J. Ellis,Doris Quinkert,Megan Baker,Raquel Lopez Ramon,Fernando Ramos Lopez,Lea Barfod,P M Folegatti,D Silman,M Datoo,Iona J. Taylor,Jing Jin,David Pulido,Alexander D. Douglas,Willem A. de Jongh,Robert Smith,Eleanor Berrie,Amy R. Noe,Carter L. Diggs,Lorraine Soisson,Rebecca Ashfield,Saul N. Faust,Anna Goodman,Alison M. Lawrie,Fay L. Nugent,Galit Alter,Carole A. Long,Simon J. Draper +50 more
TL;DR: It is shown that growth inhibition activity measured in vitro using purified immunoglobulin G (IgG) antibody strongly correlates with in vivo reduction of the parasite growth rate and also identify other antibody feature sets by systems serology, including the plasma anti-RH5 IgA1 response, that are associated with challenge outcome.