Heon Park

TL;DR: In vivo, antibody to IL- 17 inhibited chemokine expression in the brain during experimental autoimmune encephalomyelitis, whereas overexpression of IL-17 in lung epithelium caused Chemokine production and leukocyte infiltration, indicating a unique T helper lineage that regulates tissue inflammation.

TL;DR: IL-17F is an important regulator of inflammatory responses that seems to function differently than IL-17 in immune responses and diseases, and this requires IL- 17 receptor A, tumor necrosis factor receptor–associated factor 6, and Act1.

TL;DR: It is shown that mouse IL-25 is expressed by lung epithelial cells as a result of innate immune responses to allergens, and is a critical factor regulating the initiation of innate and adaptive proallergic responses.

TL;DR: In this paper, the authors demonstrate that IL-17 receptor family shares sequence homology in their intracellular region with Toll-IL-1 receptor (TIR) domains and with Act1, a novel adaptor previously reported as an NF-kappaB activator.

TL;DR: This work shows that using B cell–specific c-/N-myc double-knockout mice and Eμ- myc transgenic mice bred onto genetic backgrounds whereby B cell development is arrested, it is shown that Myc is necessary to stimulate both proliferation and differentiation in primary B cells.