Hiromi Hagiwara

TL;DR: The results suggest that ascorbic acid might promote the differentiation of ST2 cells into osteoblast-like cells by inducing the formation of a matrix of type I collagen, with subsequent activation of the signaling pathways that involve BMPs.

TL;DR: It is suggested that iron overload might give rise to osteoporosis by inhibiting osteoblast proliferation and differentiation, as well as the expression of type I collagen and protein and the activity of alkaline phosphatase.

TL;DR: The findings indicate that the olive polyphenols oleuropein and hydroxytyrosol may have critical effects on the formation and maintenance of bone, and can be used as effective remedies in the treatment of osteoporosis symptoms.

TL;DR: The results suggest that osteoclast progenitors as well as mature osteoclasts, are quercetin's target cells in relation to bone resorption, and that quercETin's suppressive effect on bone Resorption results from both its inhibitory effect on the differentiation of osteoc last progenitor cells into pOCs and from its disruptive effect on actin rings in mature osteclasts.

TL;DR: The data suggest that pharmacological blockade of astrocyte ETBR receptors following CNS injury modulates glial scar formation and may provide a more permissive substrate for neuronal survival and regeneration.