M
Motoko Ohnishi
Researcher at Chubu University
Publications - 40
Citations - 1059
Motoko Ohnishi is an academic researcher from Chubu University. The author has contributed to research in topics: Phosphatase & Protein phosphatase 2. The author has an hindex of 16, co-authored 39 publications receiving 1008 citations. Previous affiliations of Motoko Ohnishi include Tohoku University.
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Journal ArticleDOI
Regulation of the TAK1 Signaling Pathway by Protein Phosphatase 2C
Masahito Hanada,Jun Ninomiya-Tsuji,Ken-ichiro Komaki,Motoko Ohnishi,Koji Katsura,Ryunosuke Kanamaru,Kunihiro Matsumoto,Shinri Tamura +7 more
TL;DR: Results indicate that PP2Cβ negatively regulates the TAK1 signaling pathway by direct dephosphorylation of TAK2 in vitro and in vivo.
Journal ArticleDOI
Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts.
Je-Tae Woo,Hiroshi Nakagawa,Michitaka Notoya,Takayuki Yonezawa,Nobuyuki Udagawa,In-Seon Lee,Motoko Ohnishi,Hiromi Hagiwara,Kazuo Nagai +8 more
TL;DR: The results suggest that osteoclast progenitors as well as mature osteoclasts, are quercetin's target cells in relation to bone resorption, and that quercETin's suppressive effect on bone Resorption results from both its inhibitory effect on the differentiation of osteoc last progenitor cells into pOCs and from its disruptive effect on actin rings in mature osteclasts.
Journal ArticleDOI
Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells
Masahito Hanada,Takayasu Kobayashi,Motoko Ohnishi,Shoko Ikeda,Hong Wang,Koji Katsura,Yuchio Yanagawa,Akira Hiraga,Ryunosuke Kanamaru,Shinri Tamura +9 more
TL;DR: The results suggest that PP2C selectively inhibits the SAPK pathways through suppression of MKK3b, MKK4,MKK6b and MKK7 activities in mammalian cells.
Journal ArticleDOI
Regulation of stress-activated protein kinase signaling pathways by protein phosphatases.
TL;DR: The properties of the proteinosphatases responsible for the regulation of SAPK signaling pathways are described and differences in substrate specificities and regulatory mechanisms for these phosphatases form the molecular basis for the complex regulation ofSAPK signaling.
Journal ArticleDOI
Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT-A gene with the polyadenylation signal as a negative selection maker.
Yuchio Yanagawa,Takashi Kobayashi,Motoko Ohnishi,Takayasu Kobayashi,Shinri Tamura,Teruhisa Tsuzuki,Makoto Sanbo,Takeshi Yagi,Fumi Tashiro,Jun-Ichi Miyazaki +9 more
TL;DR: The results indicate that the use of DT‐ApA for negative selection together with the application of LA‐PCR for screening ensures efficient and time‐saving screening for homologous recombinants.