H
Hiroshige Itakura
Researcher at Ibaraki Christian University
Publications - 187
Citations - 12729
Hiroshige Itakura is an academic researcher from Ibaraki Christian University. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 50, co-authored 185 publications receiving 12089 citations. Previous affiliations of Hiroshige Itakura include Mochida Pharmaceutical Co., Ltd & Kindai University.
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Journal ArticleDOI
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
Mitsuhiro Yokoyama,Hideki Origasa,Masunori Matsuzaki,Yuji Matsuzawa,Yasushi Saito,Yuichi Ishikawa,Shinichi Oikawa,Jun Sasaki,Hitoshi Hishida,Hiroshige Itakura,Toru Kita,Akira Kitabatake,Noriaki Nakaya,Toshiie Sakata,Kazuyuki Shimada,Kunio Shirato +15 more
TL;DR: Testing the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish found it to be a promising treatment.
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A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection
Hiroshi Suzuki,Hiroshi Suzuki,Yukiko Kurihara,Motohiro Takeya,Nobuo Kamada,Motoyukl Kataoka,Kou-ichi Jishage,Otoya Ueda,Hisashl Sakaguchi,Takayuki Higashi,Tsukasa Suzuki,Yoshiaki Takashima,Yoshiki Kawabe,Yoshiki Kawabe,Osamu Cynshi,Youichiro Wada,Makoto Honda,Hiroki Kurihara,Hiroyuki Aburatani,Takefumi Doi,Akiyo Matsumoto,Sadahiro Azuma,Tetsuo Noda,Yutaka Toyoda,Hiroshige Itakura,Yoshio Yazaki,Seikoh Horiuchi,Kiyoshi Takahashi,J. Kar Kruijt,Theo J.C. Van Berkel,Urs P. Steinbrecher,Shun Ishibashi,Nobuyo Maeda,Siamon Gordon,Tatsuhiko Kodama +34 more
TL;DR: It is shown that targeted disruption of the MSR-A gene in mice results in a reduction in the size of atherosclerotic lesions in an animal deficient in apolipoprotein E, indicating that MSr-A may play a part in host defence against pathogens.
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Primary prevention of cardiovascular disease with pravastatin in Japan (mega study) : A prospective randomised controlled trial
Haruo Nakamura,Kikuo Arakawa,Hiroshige Itakura,Akira Kitabatake,Yoshio Goto,Takayoshi Toyota,Noriaki Nakaya,Shoji Nishimoto,Masaharu Muranaka,Akira Yamamoto,Kyoichi Mizuno,Yasuo Ohashi +11 more
TL;DR: Treatment with a low dose of pravastatin reduces the risk of coronary heart disease in Japan by much the same amount as higher doses have shown in Europe and the USA.
Journal ArticleDOI
Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions.
Akiyo Matsumoto,Makoto Naito,Hiroshige Itakura,S Ikemoto,H Asaoka,I Hayakawa,Hiroshi Kanamori,Hiroyuki Aburatani,Fumimaro Takaku,Hiroshi Suzuki +9 more
TL;DR: Two types of cDNAs for human macrophage scavenger receptors were cloned from a cDNA library derived from the phorbol ester-treated human monocytic cell line THP-1, and Immunohistochemical studies using an anti-peptide antibody indicated the presence of the scavenger receptor in the macrophages of lipid-rich atherosclerotic lesions, suggesting the involvement of scavengers receptors in atherogenesis.
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Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial.
Tomonori Nagao,Hiroyuki Watanabe,Naohiro Goto,Kouji Onizawa,Hiroyuki Taguchi,Noboru Matsuo,Takuji Yasukawa,Rikio Tsushima,Hiroyuki Shimasaki,Hiroshige Itakura +9 more
TL;DR: In contrast to TG, DG apparently suppressed accumulation of fat and possibly reduces the risk of diseases associated with visceral fat obesity.