A
Alan Tseng
Researcher at University of Illinois at Chicago
Publications - 27
Citations - 1663
Alan Tseng is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Protein kinase B & Phosphorylation. The author has an hindex of 18, co-authored 27 publications receiving 1477 citations. Previous affiliations of Alan Tseng include Brigham and Women's Hospital & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
SCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
Hiroyuki Inuzuka,Shavali Shaik,Ichiro Onoyama,Darning Gao,Alan Tseng,Richard S. Maser,Bo Zhai,Lixin Wan,Alejandro Gutierrez,Alan W. Lau,Yonghong Xiao,Amanda L. Christie,Jon C. Aster,Jeffrey Settleman,Steven P. Gygi,Andrew L. Kung,Thomas Look,Keiichi I. Nakayama,Ronald A. DePinho,Wenyi Wei +19 more
TL;DR: It is shown that the E3 ubiquitin ligase SCFFBW7 (a SKP1–cullin-1–F-box complex that contains FBW7 as the F-box protein) governs cellular apoptosis by targeting MCL1, a pro-survival BCL2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3.
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Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
TL;DR: It is shown that the serine/threonine protein kinase Akt1, but not Akt2, directly controls Skp2 stability by a mechanism that involves degradation by the APC–Cdh1 ubiquitin ligase complex.
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Phosphorylation by Casein Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase
Hiroyuki Inuzuka,Alan Tseng,Daming Gao,Bo Zhai,Qing Zhang,Shavali Shaik,Lixin Wan,Xiaolu L. Ang,Caroline Mock,Haoqiang Yin,Haoqiang Yin,Jayne M. Stommel,Steven P. Gygi,Galit Lahav,John M. Asara,Zhi Xiong Jim Xiao,William G. Kaelin,J. Wade Harper,Wenyi Wei +18 more
TL;DR: It is reported that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of MDM2 by casein kinase I (CKI) at multiple sites triggers its interaction with, and subsequent ubiquitination and destruction, by SCF(beta-TRCP).
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Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction
Darning Gao,Lixin Wan,Hiroyuki Inuzuka,Anders H. Berg,Alan Tseng,Bo Zhai,Shavali Shaik,Eric J. Bennett,Adriana E. Tron,Jessica A. Gasser,Alan W. Lau,Steven P. Gygi,J. Wade Harper,James A. DeCaprio,Alex Toker,Wenyi Wei +15 more
TL;DR: Findings indicate that the Rictor/Cullin-1 E3 ligase activity is regulated by a specific signal relay cascade and that misregulation of this mechanism may contribute to the frequent overexpression of SGK1 in various human cancers.
Journal ArticleDOI
Platelet-neutrophil interactions under thromboinflammatory conditions.
TL;DR: The current understanding of the regulatory mechanisms of platelet–neutrophil interactions in thromboinflammatory disease is discussed.