H
Hiskias G. Keizer
Researcher at Solvay
Publications - 31
Citations - 2033
Hiskias G. Keizer is an academic researcher from Solvay. The author has contributed to research in topics: Cytotoxic T cell & P-glycoprotein. The author has an hindex of 17, co-authored 30 publications receiving 1934 citations. Previous affiliations of Hiskias G. Keizer include VU University Amsterdam & Netherlands Cancer Institute.
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Journal ArticleDOI
Doxorubicin (adriamycin): a critical review of free radical-dependent mechanisms of cytotoxicity.
TL;DR: Free radical-independent cytotoxicity mechanisms, taking place in the nuclear compartment of the cell, may more likely be involved in the antitumor effect of doxorubicin.
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Bioisosteric Replacements of the Pyrazole Moiety of Rimonabant: Synthesis, Biological Properties, and Molecular Modeling Investigations of Thiazoles, Triazoles, and Imidazoles as Potent and Selective CB1 Cannabinoid Receptor Antagonists
Josephus H. M. Lange,Herman H. van Stuivenberg,Hein K. A. C. Coolen,Tiny J.P. Adolfs,Andrew C. McCreary,Hiskias G. Keizer,Henri C. Wals,Willem Veerman,Alice J.M. Borst,Wouter de Looff,Peter C Verveer,Chris G. Kruse +11 more
TL;DR: A structure-activity relationship (SAR) study revealed a close correlation between the biological results in the imidazole and pyrazole series and showed a close three-dimensional structural overlap between the key compound 62 and rimonabant.
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Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists.
Josephus H. M. Lange,Hein K. A. C. Coolen,Herman H. van Stuivenberg,Dijksman Jessica A R,Arnoud H.J. Herremans,Eric Ronken,Hiskias G. Keizer,Koos Tipker,Andrew C. McCreary,Willem Veerman,Henri C. Wals,Bob Stork,Peter C Verveer,Arnold P. den Hartog,Natasja M J de Jong,Tiny J.P. Adolfs,Jan Hoogendoorn,Chris G. Kruse +17 more
TL;DR: Replacement of the amidine -NH(2) moiety with a -NHCH(3) group proved to be the key change for gaining oral biovailability in this series of compounds leading to the identification of 80.
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Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells.
H Spits,W. C. A. Van Schooten,Hiskias G. Keizer,G A van Seventer,M van de Rijn,Cox Terhorst,J. E. De Vries +6 more
TL;DR: This work has demonstrated that conjugates of CTL's and target cells can be formed in the absence of specific antigen recognition, and indicates that nonspecific conjugate formation between C TL's andtarget cells precedes the recognition of specific antigens by the T-cell receptor.
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Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice
Irene O.C.M. Vroegrijk,Janna A. van Diepen,Sjoerd A.A. van den Berg,Irene Westbroek,Hiskias G. Keizer,Luisa Gambelli,Raquel Hontecillas,Josep Bassaganya-Riera,Gerben Zondag,Johannes A. Romijn,Louis M. Havekes,Peter J. Voshol,Peter J. Voshol +12 more
TL;DR: It is concluded that dietary PSO ameliorates high-fat diet induced obesity and insulin resistance in mice, independent of changes in food intake or energy expenditure.