Hong-Jiang Wei

TL;DR: The value ofPERV inactivation to prevent cross-species viral transmission is highlighted and the successful production of PERV-inactivated animals to address the safety concern in clinical xenotransplantation are demonstrated.

TL;DR: It is shown that pigs with all PERVs inactivated can also be genetically engineered to eliminate three xenoantigens and to express nine human transgenes that enhance the pigs' immunological compatibility and blood-coagulation compatibility with humans.

TL;DR: The DMD-modified piglet exhibited degenerative and disordered phenotypes in skeletal and cardiac muscle, and declining thickness of smooth muscle in the stomach and intestine, highlighting the high specificity of genetic modification using CRISPR/Cas9.

TL;DR: These findings demonstrate that stable iPS cells could be generated in LCDM medium, which could give rise to both embryonic and extraembryonic cells in vivo, but the efficiency and level of chimeric contribution of pig LCDM-iPS cells were found low.

TL;DR: Microsatellite analyses results indicated that the genotypes of all cloning piglets were identical to their donor cells and that the genetic homozygosity of the Banna miniature inbred pig was higher than those of the recipients, therefore, the offspring was successfully cloned using the fetal, newborn, and adult fibroblasts of Banna mini-inbred pig as donor cells.