Hongwon Kim

TL;DR: Analysis of the protein-protein interaction network in mutant organoids revealed that TXNIP, a thiol-oxidoreductase, is functionally important in the development of LRRK2-associated Parkinson's disease in a 3D environment.

TL;DR: In vivo gene editing in post-mitotic neurons of the adult brain may be a useful strategy for treating neurological diseases, and CRISPR–Cas9 nanocomplexes were effective in the adult mouse brain, with minimal off-target effects.

TL;DR: This study shows that electromagnetized gold nanoparticles (AuNPs) in the presence of specific EMF conditions facilitate an efficient direct lineage reprogramming to induced dopamine neurons in vitro and in vivo.

TL;DR: Whether graphene oxide-polyethylenimine (GO-PEI) complexes are an efficient and safe system for messenger RNA delivery for direct reprogramming of iNs and could be used to develop direct cell reprograming-based therapies for neurodegenerative diseases is investigated.

TL;DR: It is found that hypothalamic MCH biosynthesis was directly activated by acupuncture treatment and that administration of an MCH-R1 antagonist reverses the neuroprotective effects of acupuncture, and MCH showed a beneficial role in dopaminergic neuron protection via downstream pathways related to neuronal survival.