H
Huan Sun
Researcher at Chinese Academy of Sciences
Publications - 7
Citations - 511
Huan Sun is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Ligand (biochemistry) & Neutralization. The author has an hindex of 4, co-authored 7 publications receiving 187 citations.
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Journal ArticleDOI
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Lifeng Fu,Fei Ye,Yong Feng,Feng Yu,Qisheng Wang,Yan Wu,Yan Wu,Cheng Zhao,Huan Sun,Baoying Huang,Peihua Niu,Hao Song,Yi Shi,Xuebing Li,Wenjie Tan,Jianxun Qi,George F. Gao +16 more
TL;DR: It is shown that a clinically approved anti-HCV drug and a pre-clinical inhibitor against feline infectious peritonitis (corona) virus (FIPV), GC376, both efficaciously inhibit SARS-CoV-2 in Vero cells by targeting Mpro.
Journal ArticleDOI
Cross-species recognition of SARS-CoV-2 to bat ACE2.
Kefang Liu,Shuguang Tan,Sheng Niu,Sheng Niu,Jia Wang,Lili Wu,Huan Sun,Yanfang Zhang,Xiaoqian Pan,Xiao Qu,Pei Du,Yumin Meng,Yunfei Jia,Yunfei Jia,Qian Chen,Qian Chen,Chu-Xia Deng,Jinghua Yan,Hong-Wei Wang,Qihui Wang,Jianxun Qi,George F. Gao +21 more
TL;DR: The SARS-CoV-2 spike protein receptor binding domain (RBD) could bind to bACE2 from Rhinolophus macrotis (bACE2-Rm) with substantially lower affinity compared with that to the human ACE2 (hACE2) for virus infection.
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Neutralisation of ZF2001-elicited antisera to SARS-CoV-2 variants.
Xin Zhao,Anqi Zheng,Dedong Li,Rong Zhang,Huan Sun,Qihui Wang,George F. Gao,Pengcheng Han,Lianpan Dai +8 more
Journal ArticleDOI
N-glycosylation of PD-1 promotes binding of camrelizumab.
Kefang Liu,Kefang Liu,Shuguang Tan,Wanjun Jin,Jiawei Guan,Qingling Wang,Huan Sun,Jianxun Qi,Jinghua Yan,Yan Chai,Zhongfu Wang,Chu-Xia Deng,George F. Gao,George F. Gao +13 more
TL;DR: Different N‐glycan composition in PD‐1 is demonstrated, and the efficiency of camrelizumab to inhibit the binding of PD‐L1 is substantially reduced, increasing the understanding of how glycosylation affects the activity ofPD‐1‐specific MAbs during immune checkpoint therapy.
Journal ArticleDOI
Structural basis of HCoV-19 fusion core and an effective inhibition peptide against virus entry.
Huan Sun,Yan Li,Peipei Liu,Chengpeng Qiao,Xiaomin Wang,Lianao Wu,Lianao Wu,Kefang Liu,Yu Hu,Chao Su,Chao Su,Shuguang Tan,Shumei Zou,Guizhen Wu,Jinghua Yan,George F. Gao,Jianxun Qi,Qihui Wang +17 more
TL;DR: Since the end of 2019, a cluster of coronavirus disease 2019 (COVID-19) cases have been reported, with a number of cases described as "highly suggestive of influenza-like illness".