Q
Qian Chen
Researcher at Chinese Academy of Sciences
Publications - 5
Citations - 377
Qian Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Auxin & Pangolin. The author has an hindex of 4, co-authored 5 publications receiving 130 citations. Previous affiliations of Qian Chen include Anhui University & Ghent University.
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Journal ArticleDOI
Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
Lili Wu,Qian Chen,Qian Chen,Kefang Liu,Kefang Liu,Jia Wang,Pengcheng Han,Yanfang Zhang,Yu Hu,Yu Hu,Yumin Meng,Xiaoqian Pan,Chengpeng Qiao,Siyu Tian,Pei Du,Hao Song,Weifeng Shi,Jianxun Qi,Hong-Wei Wang,Jinghua Yan,George F. Gao,Qihui Wang,Qihui Wang +22 more
TL;DR: Cutting light on pursuing the intermediate host of SARS-CoV-2 is shed and the necessity of monitoring susceptible hosts to prevent further outbreaks is highlighted.
Journal ArticleDOI
Molecular insights into receptor binding of recent emerging SARS-CoV-2 variants.
Pengcheng Han,Pengcheng Han,Pengcheng Han,Chao Su,Chao Su,Yanfang Zhang,Chongzhi Bai,Anqi Zheng,Chengpeng Qiao,Qing Wang,Sheng Niu,Sheng Niu,Qian Chen,Qian Chen,Yuqin Zhang,Weiwei Li,Hanyi Liao,Jing Li,Zengyuan Zhang,Heecheol Cho,Mengsu Yang,Xiaoyu Rong,Xiaoyu Rong,Yu Hu,Yu Hu,Niu Huang,Jinghua Yan,Qihui Wang,Xin Zhao,George F. Gao,George F. Gao,Jianxun Qi +31 more
TL;DR: In this paper, the authors examined several SARS-CoV-2 variants of concern (VOCs) including Alpha, Beta, and Gamma, and demonstrated that five variants receptor-binding domain (RBD) increased binding affinity for hACE2, and four variants pseudoviruses increased entry into susceptible cells.
Journal ArticleDOI
A coherent transcriptional feed-forward motif model for mediating auxin-sensitive PIN3 expression during lateral root development
Qian Chen,Qian Chen,Yang Liu,Steven Maere,EunKyoung Lee,Gert Van Isterdael,Zidian Xie,Wei Xuan,Jessica R. Lucas,Valya Vassileva,Valya Vassileva,Saeko Kitakura,Saeko Kitakura,Peter Marhavý,Peter Marhavý,Krzysztof Wabnik,Krzysztof Wabnik,Niko Geldner,Eva Benková,Jie Le,Hidehiro Fukaki,Erich Grotewold,Chuanyou Li,Jiří Friml,Jiří Friml,Fred D. Sack,Tom Beeckman,Steffen Vanneste +27 more
TL;DR: It is proposed that AUXIN RESPONSE FACTOR7 (ARF7) and the ARF7-regulated FOUR LIPS/MYB124 (FLP) transcription factors jointly form a coherent feed-forward motif that mediates the auxin-responsive PIN3 transcription in planta to steer the early steps of lateral root formation.
Journal ArticleDOI
Cross-species recognition of SARS-CoV-2 to bat ACE2.
Kefang Liu,Shuguang Tan,Sheng Niu,Sheng Niu,Jia Wang,Lili Wu,Huan Sun,Yanfang Zhang,Xiaoqian Pan,Xiao Qu,Pei Du,Yumin Meng,Yunfei Jia,Yunfei Jia,Qian Chen,Qian Chen,Chu-Xia Deng,Jinghua Yan,Hong-Wei Wang,Qihui Wang,Jianxun Qi,George F. Gao +21 more
TL;DR: The SARS-CoV-2 spike protein receptor binding domain (RBD) could bind to bACE2 from Rhinolophus macrotis (bACE2-Rm) with substantially lower affinity compared with that to the human ACE2 (hACE2) for virus infection.
Journal ArticleDOI
Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin.
Sheng Niu,Sheng Niu,Jia Wang,Bin Bai,Lili Wu,Anqi Zheng,Qian Chen,Qian Chen,Pei Du,Pengcheng Han,Yanfang Zhang,Yunfei Jia,Yunfei Jia,Chengpeng Qiao,Jianxun Qi,Wen xia Tian,Hong-Wei Wang,Qihui Wang,George F. Gao,George F. Gao +19 more
TL;DR: In this article, the spike protein receptor-binding domain (RBD) of pangolin CoVs was found to be as efficient as the SARS-CoV-2 RBD in vitro.