H
Huidong Yuan
Researcher at University of Rochester
Publications - 7
Citations - 2070
Huidong Yuan is an academic researcher from University of Rochester. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 7, co-authored 7 publications receiving 2019 citations.
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Journal ArticleDOI
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.
Junhao Mao,Junhao Mao,Jiyong Wang,Bo Liu,Bo Liu,Weijun Pan,Gist H. Farr,Christopher Flynn,Huidong Yuan,Shinji Takada,David Kimelman,Lin Li,Dianqing Wu +12 more
TL;DR: It is concluded that the binding of Axin to LRP-5 is an important part of the Wnt signal transduction pathway, and the L RP-5 sequences involved in interactions with Axin are required for LEF-1 activation.
Journal ArticleDOI
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
Lin Li,Huidong Yuan,Carole D. Weaver,Junhao Mao,Gist H. Farr,Daniel J. Sussman,Jos Jonkers,David Kimelman,Dianqing Wu +8 more
TL;DR: The observation that the Dvl‐binding domain of either Frat1 or Axin was able to inhibit Wnt‐1‐induced LEF‐1 activation suggests that the interactions between Dvl and Axin and between DVL and Frat may be important for this signaling pathway.
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Dishevelled Proteins Lead to Two Signaling Pathways REGULATION OF LEF-1 AND c-Jun N-TERMINAL KINASE IN MAMMALIAN CELLS
Lin Li,Huidong Yuan,Wei Xie,Junhao Mao,Ann M. Caruso,Andrew P. McMahon,Daniel J. Sussman,Dianqing Wu +7 more
TL;DR: In this article, the DEP domain of Dsh/Dvl proteins was found to be essential for the activation of the c-Jun N-terminal kinase (JNK).
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Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors
TL;DR: It is found that the constitutively active forms of the α subunits of the Gqand G12 class of G proteins can activate SRF in NIH3T3 cells and that the thrombin, LPA, thromboxane A2, and endothelin receptors may be able to couple to Gα12/13.
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Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein alpha subunit Galpha13.
TL;DR: Signal transduction pathways that mediate activation of serum response factor (SRF) by heterotrimeric G protein alpha subunits were characterized in transfection systems and the synergism between Galpha13 and GEF115 indicates thatGEF115 mediates Galpha 13-induced activation of Rho and SRF.