Huimin Yan

TL;DR: Results do show that the CPE was induced by apoptosis rather than necrosis, shown by typical DNA fragmentation, through the existence of apoptotic bodies and swollen mitochondria, which has some implications for the SARS‐CoV pathogenicity.

TL;DR: It is reported that by using in vitro bio-engineering techniques, SARS-CoV HR1 and HR2 bind to each other and form a typical 6-helix bundle and lays the ground for identification of virus fusion/entry inhibitors for this devastating emerging virus.

TL;DR: The new assay, named aggregation-specific FACTT (AS-FACTT), is much more sensitive than AS-ELISA and could detect prion aggregates in the brain of mice as early as 7 days after an intraperitoneal inoculation of PrPSc, and also detects prions in blood of mule deer infected with the agent causing a naturally occurring prion disease, chronic wasting disease.

TL;DR: In insertion mutants appear to share common features, and the degree of abnormality is proportional to the number of insertions, which may contribute to the pathogenesis of inherited human prion disease.

TL;DR: A SARS-CoV in China is isolated and its genome sequences are analyzed with the aims to reveal the evolution trends of the virus and provide insights into understanding pathogenesis and SARS epidemic.