Fang Yuan

TL;DR: The molecular basis for this genetic bias is revealed from the structural and thermodynamic properties of an archetypal TRAV12-2-encoded TCR complexed to the clinically relevant heteroclitic peptide, ELAGIGILTV, bound to HLA-A*0201 (A2-ELA).

TL;DR: Results do show that the CPE was induced by apoptosis rather than necrosis, shown by typical DNA fragmentation, through the existence of apoptotic bodies and swollen mitochondria, which has some implications for the SARS‐CoV pathogenicity.

TL;DR: It is reported that by using in vitro bio-engineering techniques, SARS-CoV HR1 and HR2 bind to each other and form a typical 6-helix bundle and lays the ground for identification of virus fusion/entry inhibitors for this devastating emerging virus.

TL;DR: In this paper, the authors defined the region of HR1 that binds to HR2 by a series of biochemical and biophysical measures, and then the defined HR1 (902−952) and HR2 (1145−1184) chains, which are different from previously defined binding regions, were linked together by a flexible linker to form a single-chain construct.

TL;DR: This bundle has been analyzed by a series of biophysical and biochemical techniques and confirmed that the design technique can be used for coronavirus as it successfully used for members of paramyxoviruses.