Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.
Jieqing Zhu,Gengfu Xiao,Yanhui Xu,Fang Yuan,Congyi Zheng,Yueyong Liu,Huimin Yan,David K. Cole,John I. Bell,Zihe Rao,Po Tien,Po Tien,George F. Gao,George F. Gao +13 more
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TLDR
It is reported that by using in vitro bio-engineering techniques, SARS-CoV HR1 and HR2 bind to each other and form a typical 6-helix bundle and lays the ground for identification of virus fusion/entry inhibitors for this devastating emerging virus.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2004-06-18 and is currently open access. It has received 100 citations till now. The article focuses on the topics: Coronavirus & Fusion protein.read more
Citations
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Journal ArticleDOI
The severe acute respiratory syndrome.
TL;DR: The concerted and coordinated response that contained SARS is a triumph for global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
Journal ArticleDOI
Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection
TL;DR: The findings that horseshoe bats are the natural reservoir for SARS-CoV-like virus and that civets are the amplification host highlight the importance of wildlife and biosecurity in farms and wet markets, which can serve as the source and amplification centers for emerging infections.
Journal ArticleDOI
Viral targets for vaccines against COVID-19.
Lianpan Dai,George F. Gao +1 more
TL;DR: In this article, the authors discuss which viral elements are used in COVID-19 vaccine candidates, why they might act as good targets for the immune system and the implications for protective immunity.
Journal ArticleDOI
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
Guangwen Lu,Yawei Hu,Qihui Wang,Jianxun Qi,Feng Gao,Feng Gao,Yan Li,Yanfang Zhang,Wei Zhang,Yuan Yuan,Yuan Yuan,Jinku Bao,Buchang Zhang,Yi Shi,Jinghua Yan,George F. Gao +15 more
TL;DR: The crystal structure of the receptor binding domain of the MERS-CoV spike protein, both free and bound to the receptor, was presented in this article, which revealed a core subdomain homologous to that of the SARS-coV spike proteins, and a unique strand-dominated external receptor binding motif that recognizes blades IV and V of the CD26 β-propeller.
Journal ArticleDOI
Type III Secretion Systems and Disease
TL;DR: To facilitate patient care and improve outcomes, it is important to understand the T3 SS-mediated virulence processes and to target T3SSs in therapeutic and prophylactic development efforts.
References
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI
A novel coronavirus associated with severe acute respiratory syndrome.
Thomas G. Ksiazek,Dean D. Erdman,Cynthia S. Goldsmith,Zaki,Teresa C. T. Peret,Shannon L. Emery,Suxiang Tong,Urbani C,James A. Comer,Wilina Lim,Pierre E. Rollin,Scott F. Dowell,Ai Ee Ling,Charles D. Humphrey,Wun-Ju Shieh,Jeannette Guarner,Christopher D. Paddock,Paul A. Rota,Barry S. Fields,Joseph L. DeRisi,Jyh-Yuan Yang,Nancy J. Cox,James M. Hughes,James W. LeDuc,William J. Bellini,Larry J. Anderson +25 more
TL;DR: A novel coronavirus is associated with this outbreak of severe acute respiratory syndrome, and the evidence indicates that this virus has an etiologic role in SARS.
Journal ArticleDOI
Coronavirus as a possible cause of severe acute respiratory syndrome
Jsm Peiris,Sik To Lai,Llm Poon,Yi Guan,Lyc Yam,Wilina Lim,John M. Nicholls,Wks Yee,WW Yan,MT Cheung,V. C. C. Cheng,KH Chan,Dnc Tsang,R Yung,Ting Kin Ng,KY Yuen +15 more
TL;DR: Serological and molecular tests specific for the virus permitted a definitive laboratory diagnosis to be made and allowed further investigation to define whether other cofactors play a part in disease progression.
Journal ArticleDOI
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
John J. Skehel,Don C. Wiley +1 more
TL;DR: Comparisons to the soluble N-ethyl-maleimide-sensitive factor attachment protein receptor (SNARE) protein complex of vesicle fusion suggests that these molecules are all in the fusion-activated conformation and that the juxtaposition of the membrane anchor and fusion peptide, a recurring feature, is involved in the fused mechanism.
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