H
Hunter C. Champion
Researcher at Johns Hopkins University
Publications - 275
Citations - 23191
Hunter C. Champion is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Adrenomedullin. The author has an hindex of 74, co-authored 275 publications receiving 21959 citations. Previous affiliations of Hunter C. Champion include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
Endomorphin 1 and 2, Endogenous Ligands for the μ-opioid Receptor, Decrease Cardiac Output, and Total Peripheral Resistance in the Rat
Hunter C. Champion,James E. Zadina,James E. Zadina,Abba J. Kastin,Abba J. Kastin,László Hackler,László Hackler,Lin-Jun Ge,Lin-Jun Ge,Philip J. Kadowitz +9 more
TL;DR: It is demonstrated that the endomorphin peptides have significant vasodilator activity in the systemic vascular bed of the rat and show that this response is associated with a decrease in heart rate and cardiac output.
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β2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4.
Thomas J. LaRocca,Martina Schwarzkopf,Perry Altman,Shihong Zhang,Achla Gupta,Ivone Gomes,Zikiar Alvin,Hunter C. Champion,Georges E. Haddad,Roger J. Hajjar,Lakshmi A. Devi,Alison D. Schecter,Sima T. Tarzami +12 more
TL;DR: The CXCR4-β2AR complex could represent a hitherto unknown target for therapeutic intervention and represent a novel receptor class of cardiac modulators.
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Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats
Trinity J. Bivalacqua,Mustafa F. Usta,Hunter C. Champion,Somboon Leungwattanakij,P A Dabisch,Dennis B. McNamara,P. J. Kadowitz,Wayne J.G. Hellstrom +7 more
TL;DR: In conclusion, overexpression of eNOS and cGMP in combination with sildenafil significantly increased both the peak ICP and total ICP to CNS in the STZ-diabetic rat, which was similar to the response observed in control rats.
Journal ArticleDOI
Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat.
J. A. Santiago,Etoi A. Garrison,William L. Purnell,Raelanda E. Smith,Hunter C. Champion,David H. Coy,William A. Murphy,Philip J. Kadowitz +7 more
TL;DR: Results suggest that amino acids 15-52 and the six-membered ring structure of adrenomedullin are important for the expression of vasodilator activity in the mesenteric vascular bed of the cat.
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Establishment of a Transgenic Sickle-Cell Mouse Model to Study the Pathophysiology of Priapism
Trinity J. Bivalacqua,Biljana Musicki,Lewis L. Hsu,Lewis L. Hsu,Mark T. Gladwin,Arthur L. Burnett,Hunter C. Champion +6 more
TL;DR: The morphometric changes of the penis and exaggerated in vivo erectile responses support the use of this transgenic Sickle-cell disease animal model to study the pathophysiological mechanisms involved in sickle- cell disease-associated priapism.