H
Hunter C. Champion
Researcher at Johns Hopkins University
Publications - 275
Citations - 23191
Hunter C. Champion is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Adrenomedullin. The author has an hindex of 74, co-authored 275 publications receiving 21959 citations. Previous affiliations of Hunter C. Champion include Johns Hopkins University School of Medicine & National Institutes of Health.
Papers
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Journal ArticleDOI
Positive inotropic and lusitropic effects of HNO/NO− in failing hearts: Independence from β-adrenergic signaling
Nazareno Paolocci,Tatsuo Katori,Hunter C. Champion,Marcus E. St. John,Katrina M. Miranda,Jon M. Fukuto,David A. Wink,David A. Kass +7 more
TL;DR: HNO/NO− has positive inotropic and lusitropic action, which unlike NO/nitrates is independent and additive to β-adrenergic stimulation and stimulates CGRP release, which suggests potential of HNO/ NO− donors for the treatment of heart failure.
Journal ArticleDOI
Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.
Thomas E. Sussan,Tirumalai Rangasamy,Tirumalai Rangasamy,David J. Blake,Deepti Malhotra,Hazim El-Haddad,Djahida Bedja,Melinda S. Yates,Ponvijay Kombairaju,Masayuki Yamamoto,Karen T. Liby,Michael B. Sporn,Kathleen L. Gabrielson,Hunter C. Champion,Rubin M. Tuder,Rubin M. Tuder,Thomas W. Kensler,Shyam Biswal +17 more
TL;DR: Protection from CS-induced emphysema depended on NRF2, as Nrf2−/− mice failed to show significant reduction inAlveolar cell apoptosis and alveolar destruction after treatment with CDDO-Im, which suggests that targeting the Nrf1 pathway during the etiopathogenesis of emphySEma may represent an important approach for prophylaxis against COPD.
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L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial.
Steven P. Schulman,Lewis C. Becker,David A. Kass,Hunter C. Champion,Michael L. Terrin,Sandra A. Forman,Kavita V Ernst,Kavita V Ernst,Mark D. Kelemen,Mark D. Kelemen,Susan N. Townsend,Anne Capriotti,Joshua M. Hare,Gary Gerstenblith +13 more
TL;DR: There was no significant change from baseline to 6 months in the vascular stiffness measurements or left ventricular ejection fraction in either of the 2 groups, including those 60 years or older and the entire study group.
Journal ArticleDOI
Clinical differences between idiopathic and scleroderma-related pulmonary hypertension
Micah R. Fisher,Stephen C. Mathai,Hunter C. Champion,Reda E. Girgis,Traci Housten-Harris,Laura K. Hummers,Jerry A. Krishnan,Fredrick M. Wigley,Paul M. Hassoun +8 more
TL;DR: There are significant clinical and survival differences between IPAH and PAH-Scl, and the presence of left heart disease, although more common in PAH, was not predictive of the higher mortality in these patients.
Journal ArticleDOI
RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction
Trinity J. Bivalacqua,Hunter C. Champion,Mustafa F. Usta,Selim Cellek,Kanchan Chitaley,R. Clinton Webb,Ronald L. Lewis,Thomas M. Mills,Wayne J.G. Hellstrom,Philip J. Kadowitz +9 more
TL;DR: Data imply that inhibition of RhoA/Rho-kinase improves eNOS protein content and activity thus restoring erectile function in diabetes, demonstrating a previously undescribed mechanism for the down-regulation of penile eNos in diabetes.