H
Hunter C. Champion
Researcher at Johns Hopkins University
Publications - 275
Citations - 23191
Hunter C. Champion is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Adrenomedullin. The author has an hindex of 74, co-authored 275 publications receiving 21959 citations. Previous affiliations of Hunter C. Champion include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
Adrenomedullin Enhances Cell Proliferation and Deoxyribonucleic Acid Synthesis in Rat Adrenal Zona Glomerulosa: Receptor Subtype Involved and Signaling Mechanism
Paola G. Andreis,Anna Markowska,Hunter C. Champion,Giuseppina Mazzocchi,Ludwik K. Malendowicz,Gastone G. Nussdorfer +5 more
TL;DR: Findings indicate that ADM stimulates cell proliferation in the rat ZG, through CGRP-(8-37)- and ADM-(22-52)-sensitive receptors, and the mitogenic effect of ADM is mediated by activation of the TK-MAPK cascade, without any involvement of the adenylate cyclase/protein kinase A-, phospholipase C/ protein kinase C-, and COX- or lipoxygenase-dependent signaling pathways.
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The Endogenous Mu-Opioid Receptor Agonists Endomorphins 1 and 2 Have Novel Hypotensive Activity in the Rabbit
Hunter C. Champion,James E. Zadina,Abba J. Kastin,Laszlo Hackler,Lin-Jun Ge,Philip J. Kadowitz +5 more
TL;DR: It is demonstrated that endomorphins 1 and 2 have significant naloxone-sensitive, vasodepressor activity in the rabbit.
Journal ArticleDOI
Endomorphin 1 and 2, endogenous μ-opioid agonists, decrease systemic arterial pressure in the rat
Marc A. Czapla,Hunter C. Champion,James E. Zadina,James E. Zadina,Abba J. Kastin,Abba J. Kastin,László Hackler,László Hackler,Lin-Jun Ge,Lin-Jun Ge,Philip J. Kadowitz +10 more
TL;DR: It is demonstrated that endomorphin 1 and 2 produce significant naloxone-sensitive decreases in systemic arterial pressure.
Journal ArticleDOI
Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension.
TL;DR: The underlying basic science supporting the use of sildenafil, as well as human evidence supporting the critical role of this drug in therapy of patients with pulmonary hypertension, are discussed.
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Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice.
Mikhail Y. Maslov,Vadappuram P. Chacko,Matthias Stuber,An L. Moens,David A. Kass,Hunter C. Champion,Robert G. Weiss +6 more
TL;DR: Cardiac PCr/ATP correlated inversely with end-systolic volume and directly with EF at 6 wk but not at 3 wk, suggesting a role of sustained energetic abnormalities in evolving chamber dysfunction and remodeling.