H
Hunter C. Champion
Researcher at Johns Hopkins University
Publications - 275
Citations - 23191
Hunter C. Champion is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Adrenomedullin. The author has an hindex of 74, co-authored 275 publications receiving 21959 citations. Previous affiliations of Hunter C. Champion include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
Resistin-Like Molecule-β in Scleroderma-Associated Pulmonary Hypertension
Daniel J. Angelini,Qingning Su,Kazuyo Yamaji-Kegan,Chunling Fan,Xingwu Teng,Paul M. Hassoun,Stephen C. Yang,Hunter C. Champion,Rubin M. Tuder,Roger A. Johns +9 more
TL;DR: Results suggest that RELM-beta may be involved in the development of scleroderma-associated pulmonary hypertension.
Journal ArticleDOI
Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice
Patrick Segers,Dimitrios Georgakopoulos,Marina Afanasyeva,Hunter C. Champion,Daniel P. Judge,Huntley D Millar,Pascal Verdonck,David A. Kass,Nikos Stergiopulos,Nico Westerhof +9 more
TL;DR: It is concluded that simultaneous acquisition of Z(in) and arterial function parameters in the mouse, based solely on conductance catheter measurements, is feasible and the sensitivity of the measuring technique to induced physiological alterations in murine hemodynamics is demonstrated.
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Effect of tumour necrosis factor‐α (TNF‐α) and interferon‐γ (IFN‐γ) on human sperm motility, viability and motion parameters
Lance S. Estrada,Hunter C. Champion,Run Wang,Mahadevan Rajasekaran,Wayne J.G. Hellstrom,Bharat B. Aggarwal,Suresh C. Sikka +6 more
TL;DR: The data suggest that the common inflammatory cytokines TNF-alpha plus IFN-gamma have only partial detrimental effects on sperm motility, viability, membrane integrity and lateral head displacement, which may contribute to the poor fertilizing potential of human spermatozoa during inflammatory conditions.
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Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats.
Kanchan Chitaley,Trinity J. Bivalacqua,Hunter C. Champion,Mustafa F. Usta,Wayne J.G. Hellstrom,Thomas M. Mills,R. Clinton Webb +6 more
TL;DR: A functional role of RhoA in maintaining the flaccid penis is demonstrated and support for the inhibition of R HoA as a potential therapy for the enhancement of erectile function is provided.
Journal ArticleDOI
Alternatively spliced neuronal nitric oxide synthase mediates penile erection
K. Joseph Hurt,Sena F. Sezen,Hunter C. Champion,Julie K. Crone,Michael Palese,Paul L. Huang,Akira Sawa,Xiaojiang Luo,Biljana Musicki,Solomon H. Snyder,Arthur L. Burnett +10 more
TL;DR: It is shown that the beta splice variant of nNOS elicits normal erection despite a decrease in stimulus-response characteristics and a 5-fold increased sensitivity to the NOS inhibitor, l-NAME, and alternatively spliced forms of n NOS are major mediators of penile erection and so may be targets for therapeutic intervention.