H
Hunter C. Champion
Researcher at Johns Hopkins University
Publications - 275
Citations - 23191
Hunter C. Champion is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Pulmonary hypertension & Adrenomedullin. The author has an hindex of 74, co-authored 275 publications receiving 21959 citations. Previous affiliations of Hunter C. Champion include Johns Hopkins University School of Medicine & National Institutes of Health.
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Journal ArticleDOI
Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in isolated rat aorta.
TL;DR: It is demonstrated that the endomorphins relax aortic vascular smooth muscle from the rat aorta by an endothelium-dependant mechanism.
Journal ArticleDOI
Proadrenomedullin NH2-terminal 20 peptide has cAMP-mediated vasodilator activity in the mesenteric vascular bed of the cat.
Hunter C. Champion,C. C. Erickson,M. L. Simoneaux,Trinity J. Bivalacqua,William A. Murphy,David H. Coy,Philip J. Kadowitz +6 more
TL;DR: The present data suggest that vasodilator responses to the hPAMP and hADM are mediated by an increase in cAMP and that an interaction with the adrenergic nervous system is not involved.
Journal ArticleDOI
Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat.
Hunter C. Champion,Hunter C. Champion,Trinity J. Bivalacqua,Trinity J. Bivalacqua,Run Wang,Run Wang,Philip J. Kadowitz,Philip J. Kadowitz,Larry K. Keefer,Larry K. Keefer,Joseph E. Saavedra,Joseph E. Saavedra,Joseph A. Hrabie,Joseph A. Hrabie,Paul C. Doherty,Paul C. Doherty,Wayne J.G. Hellstrom +16 more
TL;DR: No donors caused dose-dependent increases in cavernosal pressure when administered intracavernosally and transurethrally, and these data suggest further exploration of the use of NO donors for the treatment of erectile dysfunction.
Journal ArticleDOI
Adrenomedullin(16–31) Has Pressor Activity in the Rat But Not the Cat
Hunter C. Champion,D.E Friedman,David G. Lambert,William A. Murphy,David H. Coy,Philip J. Kadowitz +5 more
TL;DR: The data suggest that increases in systemic arterial pressure in response to hADM (16-31) are mediated by release of catecholamines and activation of alpha-adrenergic receptors in the rat, and that there are marked species differences in the response to the peptide.
Journal ArticleDOI
Pharmacologic management of peripheral vascular disease
TL;DR: Although the understanding of the pathophysiology of atherosclerosis and peripheral vascular disease continues to grow, there is still no medication that can safely and efficaciously be given to most claudicants that will alleviate their symptoms to prevent disease progression.