Hyesung Jeon

TL;DR: Given such favorable properties including low toxicity, biocompatibility, and fast uptake by several nondestructive endocytic pathways, the HGC nanoparticles may serve as a versatile carrier for the intracellular delivery of therapeutic agents.

TL;DR: A facile synthesis of monodispersed mesoporous silica nanoparticles possessing very large pores and application of the nanoparticles to plasmid DNA delivery to human cells is reported on.

TL;DR: The direction of the conformational movement and the hydrophobic clustering that stabilizes the closed structure are markedly different from those of other ATP-dependent proteases, providing unprecedented insights into the activation of ClpP.

TL;DR: Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity.

TL;DR: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking, and Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.