Ian Kimber

TL;DR: Research highlights included: advances in understanding of immune responses to contact sensitisers, the importance of autoxidation or enzyme-mediated oxidation for the activation of chemicals, the mechanisms through which hapten-protein conjugates are formed and the development of novel in vitro strategies for the identification of skin-sensitising chemicals.

TL;DR: It is proposed that the more marked Th2 skewing observed in first pregnancy may, at least in part, explain the higher prevalence of atopic disease and allergy in the first born.

TL;DR: This work proposes that FnEDA+ positive feedback loops are a potential driver of Th1/Th17 inflammation, and reviews endogenous ligands for TLR in relation to inflammatory disease, Fn EDA+ function, and the potential role for FnEDa+ in psoriasis, allergic contact dermatitis, and atopic dermatitis.

TL;DR: In this paper, the authors have described a mutinyin derived from human tear lipocalin and a corresponding nucleic acid molecule encoding such a mutein, and a method for its generation.

TL;DR: The extent to which human data have been used to refine classification decisions and safety evaluations is examined critically and the question of whether, and to what extent, the identification and evaluation of skin sensitization hazards has led to an improvement of public and/or occupational health is addressed.