Ian Phillips

TL;DR: Investigation of the ability of rat hepatocytes, cultured conventionally or co-cultured with rat liver epithelial cells, to maintain the expression of genes encoding members of the CYP2B subfamily, and the inducibility of this expression by phenobarbital demonstrated that the ratios of the abundance and inducability of the two mRNAs were the same in co-culture as in vivo.

TL;DR: University of London, London, UK; Cox Associates, Denver, CO; Kansas State University, Manhattan, KS, and Livestock Information Services, Callaway, NE; JMI Laboratories, North Liberty, IA; Hartford Hospital, University of Connecticut, 80 Seymour St.

TL;DR: Human FMO2 has 51-53% primary sequence identity with human FMO1, rabbit pulmonary FMO and rabbit liver FMO form 2, and thus represents a fourth, distinct, member of the mammalian FMO family.

TL;DR: A survey of g.23238C>T variation across Africa revealed that the distribution of this SNP is relatively homogeneous across sub-Saharan Africa, with approximately one third of individuals possessing at least one FMO2*1 allele, though in some populations the incidence of these individuals approached 50%.

TL;DR: NADPH-cytochrome c (P-450) reductase from liver microsomes of phenobarbital-treated rats has been purified in a single step by affinity chromatography on agarose-hexane-adenosine 2',5'-diphosphate.